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1. WO2020108500 - HISTONE ACETYLASE P300 INHIBITOR AND USE THEREOF

Publication Number WO/2020/108500
Publication Date 04.06.2020
International Application No. PCT/CN2019/121086
International Filing Date 27.11.2019
IPC
C07D 235/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
C07D 263/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
263Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
52condensed with carbocyclic rings or ring systems
C07D 269/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
269Heterocyclic compounds containing rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms according to more than one of groups C07D261/-C07D267/204
02having the hetero atoms in positions 1 and 3
C07D 277/60 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
60condensed with carbocyclic rings or ring systems
C07D 283/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
283Heterocyclic compounds containing rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms, according to more than one of groups C07D275/-C07D281/205
02having the hetero atoms in positions 1 and 3
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/381
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
381having five-membered rings
A61K 31/4184
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
A61K 31/423
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
42Oxazoles
423condensed with carbocyclic rings
A61K 31/4245
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
4245Oxadiazoles
A61K 31/428
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
428condensed with carbocyclic rings
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
Applicants
  • 成都海创药业有限公司 HINOVA PHARMACEUTICALS INC. [CN]/[CN]
Inventors
  • 樊磊 FAN, Lei
  • 王飞 WANG, Fei
  • 吴孝全 WU, Xiaoquan
  • 胥珂馨 XU, Kexin
  • 陈锞 CHEN, Ke
  • 罗童川 LUO, Tongchuan
  • 张少华 ZHANG, Shaohua
  • 杜武 DU, Wu
  • 张承智 ZHANG, Chengzhi
  • 霍永旭 HUO, Yongxu
  • 涂志林 TU, Zhilin
  • 李兴海 LI, Xinghai
  • 陈元伟 CHEN, Yuanwei
Agents
  • 成都高远知识产权代理事务所(普通合伙) GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP)
Priority Data
201811427686.727.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) HISTONE ACETYLASE P300 INHIBITOR AND USE THEREOF
(FR) INHIBITEUR D'HISTONE ACÉTYLASE P300 ET UTILISATION ASSOCIÉE
(ZH) 一类组蛋白乙酰化酶p300抑制剂及其用途
Abstract
(EN)
Provided are a histone acetylase p300 inhibitor and a use thereof, belonging to the field of medicinal chemistry technology. A compound represented by formula (I), or a stereochemical isomer thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, can inhibit the activity of histone acetylase p300 and inhibit the proliferation activity of a variety of tumor cells.
(FR)
L'invention concerne un inhibiteur d'histone acétylase p300 et son utilisation, se rapportant au domaine de la technologie de chimie médicinale. L'invention concerne un composé représenté par la formule (I), ou un isomère stéréochimique, ou un solvate, ou un sel pharmaceutiquement acceptable de celui-ci, qui peut inhiber l'activité de l'histone acétylase p300 et l'activité de prolifération d'une variété de cellules tumorales. Drawing_references_to_be_translated:
(ZH)
一类组蛋白乙酰化酶p300抑制剂及其用途,属于药物化学技术领域。一类式(Ⅰ)所示化合物、或其立体化学异构体,或其溶剂合物、或其药学上可接受的盐,能够抑制组蛋白乙酰化酶p300的活性,能够抑制多种肿瘤细胞的增殖活性。
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