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1. WO2020108463 - HUMANIZED ANTI-HUMAN OX40 MONOCLONAL ANTIBODY, PREPARATION METHOD THEREFOR AND USE THEREOF

Publication Number WO/2020/108463
Publication Date 04.06.2020
International Application No. PCT/CN2019/120808
International Filing Date 26.11.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C12N 15/13 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Applicants
  • 南京金斯瑞生物科技有限公司 NANJINGJINSIRUI SCIENCE & TECHNOLOGY BIOLOGY CORP. [CN]/[CN]
Inventors
  • 殷刘松 YIN, Liusong
  • 周铁林 ZHOU, Tielin
  • 蒋忻坡 JIANG, Xinpo
  • 方卓 FANG, Zhuo
  • 米艳玲 MI, Yanling
  • 吴瑃辰 WU, Chunchen
Agents
  • 北京华睿卓成知识产权代理事务所(普通合伙) CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE
Priority Data
201811420381.326.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) HUMANIZED ANTI-HUMAN OX40 MONOCLONAL ANTIBODY, PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) ANTICORPS MONOCLONAL HUMANISÉ ANTI-OX40, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 人源化抗人OX40单克隆抗体及其制备方法和用途
Abstract
(EN)
The present invention relates to a humanized anti-human OX40 monoclonal antibody, a preparation method therefor and the use thereof. The humanized anti-human OX40 monoclonal antibody provided by the present invention has a high affinity and a high specificity for OX40, and can stimulate T cells to secrete cytokines, for example, the monoclonal antibody specifically activates the immune positive regulation of OX40, thereby activating T cells in order to make same secrete cytokines. Therefore, the functional humanized anti-human OX40 monoclonal antibody provided by the present invention can activate T cells by means of activating the OX40 signaling pathway, thereby realizing the purpose of tumor immunotherapy.
(FR)
La présente invention concerne un anticorps monoclonal humanisé anti-OX40, son procédé de préparation et son utilisation. L'anticorps monoclonal humanisé anti-OX40 fourni par la présente invention a une affinité élevée et une haute spécificité pour OX40, et peut stimuler des lymphocytes T pour sécréter des cytokines, par exemple, l'anticorps monoclonal active de manière spécifique la régulation positive immunitaire de OX40, activant ainsi des lymphocytes T pour sécréter des cytokines. Par conséquent, l'anticorps monoclonal humanisé anti-OX40 fonctionnel fourni par la présente invention peut activer des lymphocytes T par activation de la voie de signalisation OX40, ce qui permet d'obtenir une immunothérapie antitumorale.
(ZH)
本发明涉及一种人源化抗人OX40单克隆抗体及其制备方法和用途。本发明提供的人源化抗人OX40单克隆抗体对OX40具有高亲和性、高特异性,能够刺激T细胞分泌细胞因子,例如特异地激活OX40的免疫正调节,激活T细胞分泌细胞因子。因而,本发明提供的功能性人源化抗人OX40单克隆抗体,可通过激活OX40信号通路来激活T细胞,进而实现肿瘤免疫治疗的目的。
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