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1. WO2020108415 - INTERMEDIATE COMPOUND OF TRK KINASE INHIBITOR COMPOUND AND PREPARATION METHOD

Publication Number WO/2020/108415
Publication Date 04.06.2020
International Application No. PCT/CN2019/120441
International Filing Date 23.11.2019
IPC
C07D 471/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12in which the condensed system contains three hetero rings
C07D 471/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
22in which the condensed systems contains four or more hetero rings
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
12in which the condensed system contains three hetero rings
C07D 471/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
22in which the condensed systems contains four or more hetero rings
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 成都先导药物开发股份有限公司 HITGEN INC. [CN]/[CN]
Inventors
  • 李进 LI, Jin
  • 张登友 ZHANG, Dengyou
  • 冯静超 FENG, Jingchao
  • 廖伟 LIAO, Wei
  • 陈伟 CHEN, Wei
Agents
  • 成都高远知识产权代理事务所(普通合伙) GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP)
Priority Data
201811457027.830.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) INTERMEDIATE COMPOUND OF TRK KINASE INHIBITOR COMPOUND AND PREPARATION METHOD
(FR) COMPOSÉ INTERMÉDIAIRE D'UN COMPOSÉ INHIBITEUR DE KINASE TRK ET PROCÉDÉ DE PRÉPARATION
(ZH) 一种TRK激酶抑制剂化合物的中间体化合物及制备方法
Abstract
(EN)
An intermediate compound formula (VIII) of a TRK kinase inhibitor compound, a preparation method therefor and a use thereof in preparing a compound of formula (I). The method has high yield and is suitable for mass production.
(FR)
L'invention concerne un composé intermédiaire de formule (VIII) d'un composé inhibiteur de kinase TRK, son procédé de préparation et son utilisation dans la préparation d'un composé de formule (I). Le procédé présente un rendement élevé et est approprié pour une production à grande échelle.
(ZH)
一种TRK激酶抑制剂化合物的中间体化合物式(VIII)、其制备方法,以及将其应用于制备式(I)化合物的用途,该方法获得的产物收率高,适用于规模化生产。
Also published as
Latest bibliographic data on file with the International Bureau