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1. WO2020108407 - CLASS OF BIPIPERIDINE DERIVATIVES AS ANTITUMOR DRUG

Publication Number WO/2020/108407
Publication Date 04.06.2020
International Application No. PCT/CN2019/120319
International Filing Date 22.11.2019
IPC
C07D 473/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
02with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6
16two nitrogen atoms
A61K 31/52 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 31/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
CPC
A61K 31/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07D 473/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
02with oxygen, sulfur or nitrogen atoms directly attached in positions 2 and 6
16two nitrogen atoms
Applicants
  • 天津科技大学 TIANJIN UNIVERSITY OF SINCE AND TECHNOLOGY [CN]/[CN]
Inventors
  • 盖伦斯·赫维 GALONS, Herve
  • 郁彭 YU, Peng
  • 奥马塔·纳西米亚 OUMATA, Nassima
  • 芦逵 LU, Kui
  • 滕玉鸥 TENG, Yuou
  • 张倩 ZHANG, Qian
  • 赵连波 ZHAO, Lianbo
Agents
  • 深圳市尔逊专利代理事务所(普通合伙) SHENZHEN ELSON PATENT AGENT FIRM (GENERAL PARTNERSHIP)
Priority Data
201811416920.626.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CLASS OF BIPIPERIDINE DERIVATIVES AS ANTITUMOR DRUG
(FR) CLASSE DE DÉRIVÉS DE BIPIPÉRIDINE EN TANT QUE MÉDICAMENT ANTITUMORAL
(ZH) 一类联哌啶衍生物作为抗肿瘤药物
Abstract
(EN)
Provided is a compound represented by formula (I) serving as an inhibitor of cyclin-dependent kinase 7 (CDK7), a pharmaceutical composition thereof, and a method of using the same. Proposed is a use of the compound or the pharmaceutical composition. Representative compounds show anti-cell proliferation and anti-angiogenic activity. Some compounds are more effective than existing anticancer drugs on the market, such as sunitinib. Accordingly, in some aspects, the compound can be used for preparing drugs for treating abnormal cell proliferation or diseases related to angiogenesis, such as antitumor drugs, leukemia drugs and antiviral drugs.
(FR)
L'invention concerne un composé représenté par la formule (I) servant d'inhibiteur de la kinase cycline-dépendante 7 (CDK7), une composition pharmaceutique le comprenant, et un procédé d'utilisation associé. L'invention concerne également l'utilisation du composé ou de la composition pharmaceutique. Les composés représentatifs présentent une prolifération cellulaire et une activité anti-angiogénique. Certains composés sont plus efficaces que les médicaments anticancéreux existants sur le marché, tels que le sunitinib. Par conséquent, dans certains aspects, le composé peut être utilisé pour préparer des médicaments pour traiter une prolifération cellulaire anormale ou des maladies associées à l'angiogenèse, telles que des médicaments antitumoraux, des médicaments pour la leucémie et des médicaments antiviraux.
(ZH)
提供作为周期蛋白依赖性激酶7(CDK7)的抑制剂的如式(I)的化合物、药学组合物,以及其使用方法。提出了一种该化合物或其药物组合物的用途。有代表性的化合物表现出了抗细胞增殖和抗血管形成活性。有些化合物较市场上已有的抗癌药如舒尼替尼更为有效。相应地,在有些方面,该化合物可以用于制备治疗细胞增殖异常,或和血管增生相关疾病,例如制备抗肿瘤、白血病和抗病毒药物。
Also published as
Latest bibliographic data on file with the International Bureau