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1. WO2020108343 - ORAL PHARMACEUTICAL COMPOSITION USING 4'-THIONUCLEOSIDE COMPOUND AS ACTIVE INGREDIENT, PREPARATION METHOD THEREFOR AND USE THEREOF

Publication Number WO/2020/108343
Publication Date 04.06.2020
International Application No. PCT/CN2019/119342
International Filing Date 19.11.2019
IPC
A61K 9/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 9/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
C07H 19/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
10with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C07H 19/20 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
20with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C07H 1/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
A61K 31/7076 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
CPC
A61K 31/7068
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A61K 31/7076
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
A61K 9/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
A61K 9/48
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
Applicants
  • 四川科伦博泰生物医药股份有限公司 SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 蔡孟锬 CAI, Mengtan
  • 王梦馨 WANG, Mengxin
  • 李岩 LI, Yan
  • 葛鹏金 GE, Pengjin
  • 周丹 ZHOU, Dan
  • 宋宏梅 SONG, Hongmei
  • 蔡家强 CAI, Jiaqiang
  • 赵曦 ZHAO, Xi
  • 赵栋 ZHAO, Dong
  • 王利春 WANG, Lichun
  • 薛彤彤 XUE, Tongtong
  • 王晶翼 WANG, Jingyi
Agents
  • 北京永新同创知识产权代理有限公司 NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD.
Priority Data
201811431956.128.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ORAL PHARMACEUTICAL COMPOSITION USING 4'-THIONUCLEOSIDE COMPOUND AS ACTIVE INGREDIENT, PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) COMPOSITION PHARMACEUTIQUE ORALE UTILISANT UN COMPOSÉ DE 4'-THIONUCLÉOSIDE COMME PRINCIPE ACTIF, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 以4'-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途
Abstract
(EN)
(I) An oral pharmaceutical composition containing a 4'-thionucleoside compound of formula (I), a capsule and a product containing same, and a preparation method therefor and the use thereof. The oral pharmaceutical composition has a good stability (the active ingredient contained therein has a good stability, and only a small amount of impurities are generated) and good pharmacokinetic properties, and is easy to prepare, and can also meet the needs of clinical and commercial uses thereof.
(FR)
L'invention concerne une composition pharmaceutique orale contenant un composé de 4'-thionucléoside de formule (I), une capsule et un produit la contenant, et son procédé de préparation et son utilisation. La composition pharmaceutique orale présente une bonne stabilité (le principe actif qu'elle contient possède une bonne stabilité et seule une petite quantité d'impuretés est générée) et de bonnes propriétés pharmacocinétiques, est facile à préparer et peut également répondre aux besoins d'utilisations cliniques et commerciales associées.
(ZH)
(I)包含式(I)的4'-硫代核苷类化合物的口服药物组合物、包含其的胶囊剂、制品及其制备方法和用途,所述口服药物组合物具有良好的稳定性(所包含的活性成分具有良好的稳定性,且杂质生成量较小)、良好的药物代谢动力学性质,且便于制备,可以满足临床和商业使用的需求。
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