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1. WO2020107987 - ERK INHIBITOR CONTAINING ISOINDOLINE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Publication Number WO/2020/107987
Publication Date 04.06.2020
International Application No. PCT/CN2019/104110
International Filing Date 03.09.2019
IPC
C07D 405/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 403/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
C07D 403/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 417/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
A61K 31/506 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 403/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 403/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
14containing three or more hetero rings
C07D 405/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
14containing three or more hetero rings
Applicants
  • 中国药科大学 CHINA PHARMACEUTICAL UNIVERSITY [CN]/[CN]
Inventors
  • 徐云根 XU, Yungen
  • 纪德重 JI, Dezhong
  • 张灵芝 ZHANG, Lingzhi
  • 朱启华 ZHU, Qihua
  • 柏英 BAI, Ying
  • 吴尧尧 WU, Yaoyao
Agents
  • 南京苏高专利商标事务所(普通合伙) NANJING SUGAO PATENT AND TRADEMARK FIRM ( ORDINARY PARTNERSHIP )
Priority Data
201811424530.327.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ERK INHIBITOR CONTAINING ISOINDOLINE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
(FR) INHIBITEUR DE ERK COMPRENANT DE L'ISOINDOLINE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 含异吲哚啉酮的ERK抑制剂及其制备方法与用途
Abstract
(EN)
An isoindoline derivative, in particular a compound containing a structure of 6-(2-aminopyrimidin-4-yl)isoindolinon-1-one; and a preparation method for the isoindoline derivative. Further disclosed are an application of the isoindoline derivative and a stereoisomer, hydrate, solvate or crystal thereof, as well as a composition comprising the isoindoline derivative or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable carrier in the preparation of ERK kinase inhibitors, and a use of a pharmaceutical composition containing such compounds in the preparation of anti-tumor drugs.
(FR)
L'invention concerne un dérivé d'isoindoline, en particulier un composé contenant une structure de 6-(2-aminopyrimidin-4-yl)isoindolinon-1-one ; et un procédé de préparation du dérivé d'isoindoline. L'invention concerne en outre l'utilisation du dérivé d'isoindoline et d'un stéréoisomère, hydrate, solvate ou d'un cristal de celui-ci, ainsi qu'une composition comprenant le dérivé d'isoindoline ou un sel pharmaceutiquement acceptable de celui-ci et un véhicule pharmaceutiquement acceptable dans la préparation d'inhibiteurs de kinase ERK, et l'utilisation d'une composition pharmaceutique contenant de tels composés dans la préparation de médicaments antitumoraux.
(ZH)
一种异吲哚啉酮类衍生物,具体是一类含有6-(2-氨基嘧啶-4-基)异吲哚啉-1-酮结构的化合物;以及所述异吲哚啉酮类衍生物的制备方法。还公开了所述异吲哚啉酮类衍生物及其立体异构体、水合物、溶剂合物或结晶,以及含有所述异吲哚啉酮类衍生物或其药学上可接受的盐及药学上可接受的载体的组合物在制备ERK激酶抑制剂中的应用,以及含有这些化合物的药物组合物在制备抗肿瘤药物方面的用途。
Also published as
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