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1. WO2020107913 - COMPOUND OR SALT THEREOF, PREPARATION METHOD AND USES THEREOF

Publication Number WO/2020/107913
Publication Date 04.06.2020
International Application No. PCT/CN2019/097806
International Filing Date 26.07.2019
IPC
C07C 213/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
C07C 213/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
08by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
C07C 215/60 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
215Compounds containing amino and hydroxy groups bound to the same carbon skeleton
46having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
56with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
58with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
60the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
C07C 209/68 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
68from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
CPC
C07C 209/68
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
68from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
C07C 213/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
C07C 213/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
08by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
C07C 215/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
215Compounds containing amino and hydroxy groups bound to the same carbon skeleton
46having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
56with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
58with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
60the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
C07C 45/68
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61by reactions not involving the formation of >C = O groups
67by isomerisation; by change of size of the carbon skeleton
68by increase in the number of carbon atoms
C07C 49/84
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
49Ketones; Ketenes; Dimeric ketenes
76Ketones containing a keto group bound to a six-membered aromatic ring
84containing ether groups, groups, groups, or groups
Applicants
  • 盈科瑞(天津)创新医药研究有限公司 INCREASEPHARM (TIANJIN) INSTITUTE CO., LTD [CN]/[CN]
Inventors
  • 张保献 ZHANG, Baoxian
  • 胡杰 HU, Jie
  • 闫东辉 YAN, Donghui
  • 秦梦芝 QIN, Mengzhi
  • 曹瑛 CAO, Ying
Agents
  • 中国国际贸易促进委员会专利商标事务所 CCPIT PATENT AND TRADEMARK LAW OFFICE
Priority Data
201811417984.826.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) COMPOUND OR SALT THEREOF, PREPARATION METHOD AND USES THEREOF
(FR) COMPOSÉ OU SON SEL, SON PROCÉDÉ DE PRÉPARATION ET SES APPLICATIONS
(ZH) 化合物或其盐、其制备方法及应用
Abstract
(EN)
The present invention discloses a compound shown in a formula I or a salt thereof, wherein R1 is selected from hydrogen, hydroxyl, C1-6 alkyl, substituted C1-6 alkyl, halogen, amino and thiol wherein the substituted C1-6 alkyl group is substituted by one or more halogens. The compound or the salt thereof can be used as impurity reference standard for monitoring the introduction of impurities in the synthesis process of terbutaline or pharmaceutically acceptable salt thereof, so as to ensure efficacy and safety of a drug product.
(FR)
L’invention concerne un composé de formule I ou son sel, selon laquelle R1 est sélection dans un hydrogne, hydroxyle, alkyle C1-6, alkyle C1-6 substitué, halogène, amino et thiol, l’alkyle C1-6 étant substituté par un ou plusieurs halogènes. Le composé ou son sel peut servir d’étalon de référence d’impuretés pour contrôler l’introduction d’impuretés dans le processus de synthèse de terbutaline ou son sel pharmaceutiquement acceptable de manière à assurer l’efficacité et la sécurité du produit médicamenteux.
(ZH)
本发明公开了式Ⅰ所示的化合物或其盐,其中,R 1选自氢、羟基、C 1-6烷基、取代的C 1-6烷基、卤素、氨基和巯基;所述取代的C 1-6烷基是被一个或多个卤素取代。本发明化合物或其盐可作为杂质对照品用于监控特布他林或其药学上可接受盐的合成过程中的杂质引入,从而确保药物产品的药效和安全性。
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