WO2020102324 LIQUIDLY INJECTABLE, SELF-STABILIZING BIOPOLYMERS FOR THE DELIVERY OF RADIONUCLIDE

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Publication Number WO/2020/102324

Publication Date 22.05.2020

International Application No. PCT/US2019/061144

International Filing Date 13.11.2019

IPC

CPC

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Applicants

DUKE UNIVERSITY [US]/[US]

Inventors

CHILKOTI, Ashutosh
SCHAAL, Jeffrey, L.
LIU, Wenge

Agents

LANGER, Michael, R.
HARTWIG, Gregory, J.
ZERN, Blaine, J.

Priority Data

62/767,736

15.11.2018

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) LIQUIDLY INJECTABLE, SELF-STABILIZING BIOPOLYMERS FOR THE DELIVERY OF RADIONUCLIDE

(FR) BIOPOLYMÈRES AUTO-STABILISANTS INJECTABLES SOUS FORME LIQUIDE, POUR L'ADMINISTRATION DE RADIONUCLÉIDES

Abstract

(EN) Described herein are compositions for liquidly injectable, self-stabilizing biopolymers for the delivery of radionuclide brachytherapy. Also described herein are methods of using the compositions.

(FR) L'invention concerne des compositions pour biopolymères auto-stabilisants injectables sous forme liquide, pour l'administration d'une curiethérapie par radionucléides. L'invention concerne également des méthodes d'utilisation de ces compositions.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49	Preparations for testing in vivo
06	Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08	characterised by the carrier
10	Organic compounds
14	Peptides, e.g. proteins

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39	Medicinal preparations containing antigens or antibodies
395	Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44	Antibodies bound to carriers

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides
04	Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08	Peptides having 5 to 11 amino acids

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
78	Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49	Preparations for testing in vivo
06	Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08	characterised by the carrier
10	Organic compounds
14	Peptides, e.g. proteins

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1. WO2020102324 - LIQUIDLY INJECTABLE, SELF-STABILIZING BIOPOLYMERS FOR THE DELIVERY OF RADIONUCLIDE

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid
64	Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69	the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6905	the form being a colloid or an emulsion
6907	the form being a microemulsion, nanoemulsion or micelle

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51	Preparations containing radioactive substances for use in therapy or testing in vivo
12	characterised by a special physical form, e.g. emulsion, microcapsules, liposomes ; , characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
1217	Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
1227	Micelles, e.g. phospholipidic or polymeric micelles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid
64	Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent