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1. WO2020097624 - AN LNCRNA INTEGRATES A DNA-PK-MEDIATED DNA DAMAGE RESPONSE AND VASCULAR SENESCENCE

Publication Number WO/2020/097624
Publication Date 14.05.2020
International Application No. PCT/US2019/061006
International Filing Date 12.11.2019
IPC
C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
Applicants
  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US]/[US]
  • HAEMMIG, Stefan [CH]/[US]
Inventors
  • HAEMMIG, Stefan
  • FEINBERG, Mark W.
Agents
  • DEYOUNG, Janice Kugler
  • FASSE, J. Peter
Priority Data
62/757,83209.11.2018US
62/905,47925.09.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AN LNCRNA INTEGRATES A DNA-PK-MEDIATED DNA DAMAGE RESPONSE AND VASCULAR SENESCENCE
(FR) LONG ARN NON CODANT INTÉGRANT LA SÉNESCENCE VASCULAIRE ET UNE RÉPONSE AUX DOMMAGES DE L'ADN MÉDIÉE PAR L'ADN-PK
Abstract
(EN)
Methods and compositions for use in treating subjects suffering from a disease associated with a malfunction in DNA repair response using compositions that comprise or encode SNHG12 long non-coding RNA.
(FR)
La présente invention concerne des procédés et des compositions destinés à être utilisés dans le traitement de sujets souffrant d'une maladie associée à un dysfonctionnement dans la réponse réparatrice de l'ADN en utilisant des compositions qui comprennent un long ARN non codant du SNHG12 ou qui codent pour celui-ci.
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