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1. WO2020097614 - HYBRID IMMOLATIVE CELL-PENETRATING COMPLEXES FOR NUCLEIC ACID DELIVERY

Publication Number WO/2020/097614
Publication Date 14.05.2020
International Application No. PCT/US2019/060807
International Filing Date 11.11.2019
IPC
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
A61K 47/69 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
Applicants
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US]/[US]
  • BLAKE, Tim, R. [US]/[US]
  • WAYMOUTH, Robert, M. [US]/[US]
  • WENDER, Paul [US]/[US]
Inventors
  • BLAKE, Tim, R.
  • WAYMOUTH, Robert, M.
  • WENDER, Paul
  • LEVY, Ronald
  • HAABETH, Ole Audun, Werner
  • FRANK, Matthew
  • SALLETS, Adrienne
Agents
  • HETZER-EGGER, Claudia, H.
  • CHEN, Yuwei
  • ADAMS, Lisa
  • AMENDT, Kevin, C.
  • AZRIN, Linda, B.
Priority Data
62/758,48709.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HYBRID IMMOLATIVE CELL-PENETRATING COMPLEXES FOR NUCLEIC ACID DELIVERY
(FR) COMPLEXES DE PÉNÉTRATION CELLULAIRE IMMOLATEURS HYBRIDES POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
Abstract
(EN)
There are provided herein, inter alia, complexes, compositions and methods for the delivery of nucleic acid into a cell in vivo. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.
(FR)
L'invention concerne, entre autres, des complexes, des compositions et des procédés pour l'administration d'acide nucléique dans une cellule in vivo. Les complexes, compositions et procédés peuvent permettre la complexation, la protection, l'administration et la libération d'oligonucléotides et de protéines cargo polyanioniques dans des cellules, des tissus et des organes cibles à la fois in vitro et in vivo.
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