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1. WO2020097540 - LIPID NANOPARTICLE FORMULATIONS

Publication Number WO/2020/097540
Publication Date 14.05.2020
International Application No. PCT/US2019/060582
International Filing Date 08.11.2019
IPC
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
A61K 9/51 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
B82Y 5/00 2011.01
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Applicants
  • ARBUTUS BIOPHARMA CORPORATION [CA]/[US]
  • HEYES, James [GB]/[CA]
  • JUDGE, Adam [GB]/[CA]
  • LAM, Kieu Mong [CA]/[CA]
  • PALMER, Lorne Ralph [CA]/[CA]
  • SCHREINER, Petra [CA]/[CA]
Inventors
  • HEYES, James
  • JUDGE, Adam
  • LAM, Kieu Mong
  • PALMER, Lorne Ralph
  • SCHREINER, Petra
Agents
  • MALEN, Peter L.
  • HARRIS, Robert J.
  • VIKSNINS, Ann S.
  • KRUEGER, Katherine A.D.
  • ANDRUS, Alex
  • MICKELSON, John W.
  • NIU, Lin
  • PADYS, Danny J.
Priority Data
62/758,08809.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LIPID NANOPARTICLE FORMULATIONS
(FR) FORMULATIONS DE NANOPARTICULES LIPIDIQUES
Abstract
(EN)
The invention provides certain specific lipid nanoparticles comprising: (a) one or more nucleic acid molecules; (b) cholesterol; (c) DSPC; (d) PEG-C-DMA; and (e) a cationic lipid; and pharmaceutical compositions comprising the lipid nanoparticles. The lipid nanoparticles and pharmaceutical compositions are particularly useful for delivering a nucleic acid such as siRNA or mRNA to a patient (e.g. a human) or to a cell.
(FR)
L'invention concerne certaines nanoparticules lipidiques spécifiques comprenant : (a) une ou plusieurs molécules d'acide nucléique; (b) le cholestérol; (c) DSPC; (d) PEG-C-DMA; et (e) un lipide cationique; et des compositions pharmaceutiques comprenant les nanoparticules lipidiques. Les nanoparticules lipidiques et les compositions pharmaceutiques sont particulièrement utiles pour administrer un acide nucléique tel qu'un ARNsi ou un ARNm à un patient (par exemple un être humain) ou à une cellule.
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