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1. WO2020097537 - FUSED RING COMPOUNDS

Publication Number WO/2020/097537
Publication Date 14.05.2020
International Application No. PCT/US2019/060578
International Filing Date 08.11.2019
IPC
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 401/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
A61K 31/517 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
Applicants
  • GENENTECH, INC. [US]/[US] (US)
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AllExceptUS)
Inventors
  • MALHOTRA, Sushant
  • XIN, Jianfeng
Agents
  • ALLEN, Derick E.
  • AMODIO, Lucas M.
  • ATKINS, Bruce T.
  • BLOCK, Zachary J.
  • BRENNAN, Patrick E.
  • COYLE, Patrick J.
  • FITZGERALD, Daniel M.
  • FLOREK, Erin M.
  • GOFF, Christopher M.
  • HARPER, James D.
  • HARPER, Jesse S.
  • HEINEN JR., James M.
  • HILMERT, Laura J.
  • KEPPEL, Nicholas A.
  • LONGMEYER, Michael H.
  • MUELLER, Jacob R.
  • MUNSELL, Michael G.
  • POLAND, Eric G.
  • RASCHE, Patrick W.
  • REESER III, Robert B.
  • SCHUTH, Richard A.
  • SNIDER, Josh C.
  • TRUITT, Tracey S.
  • VANDER MOLEN, Michael J.
  • WULLER, Adam R.
  • ZYCHLEWICZ, William J.
  • BENNETT, Rachel
  • BRACCIANO, Daniel D.
  • BUTLER, Christopher H.
  • KU, Deborah S.
  • MARTINEZ, Alexandra
  • SCHNEIDERJOHN, Robert L.
  • GOLTERMAN, Robert E.
  • MOLLER-JACOBS, Rose L.
  • ROSS, Katherine L.
  • VANENGELEN, Catherine E.
  • VANENGELEN, Michael R.
  • WIERSMA, Zachary
Priority Data
PCT/CN2018/11478809.11.2018CN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FUSED RING COMPOUNDS
(FR) COMPOSÉS CYCLIQUES FONDUS
Abstract
(EN)
This invention pertains to fused ring compounds of Formula (I), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods of treatment by their administration.
(FR)
L'invention concerne des composés cycliques fondus de formule (I), tels que décrits dans la description, qui sont utilisés pour l'inhibition de protéines Ras, ainsi que des compositions comprenant ces composés et des méthodes de traitement impliquant leur administration.
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