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1. WO2020097400 - IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF

Publication Number WO/2020/097400
Publication Date 14.05.2020
International Application No. PCT/US2019/060363
International Filing Date 07.11.2019
IPC
C07D 257/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
10condensed with carbocyclic rings or ring systems
12Six-membered rings having four nitrogen atoms
A61K 31/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K 31/41 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A61K 31/4196 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41961,2,4-Triazoles
C07D 257/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
08Six-membered rings
Applicants
  • DANA-FARBER CANCER INSTITUTE, INC. [US]/[US]
Inventors
  • GRAY, Nathanael, S.
  • ZHANG, Tinghu
  • LIU, Yao
  • HE, Zhixiang
  • HAO, Mingfeng
  • WEINSTOCK, David
  • LI, Loretta, Sze-mun
Agents
  • ZHANG, William, Wei
  • ALAM, Saad
  • AMUNDSEN, Eric, L.
  • ATTISHA, Michael, J.
  • BAKER, C., Hunter
Priority Data
62/757,12407.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF
(FR) DÉRIVÉS D'IMIDAZOPYRIDINE ET DÉRIVÉS D'AZA-IMIDAZOPYRIDINE UTILISÉS COMME INHIBITEURS DE LA JANUS KINASE 2 ET UTILISATIONS ASSOCIÉES
Abstract
(EN)
The present disclosure provides compounds of Formula (I´) (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, cocrystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., Janus kinase (JAK), e.g., Janus kinase 2 (JAK2)) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating a disease (e.g., proliferative disease) in a subject in need thereof).
(FR)
L'invention concerne des composés de formule (I') (par exemple des composés de formule (I)) et leurs sels, solvates, hydrates, polymorphes, cocristaux, tautomères, stéréoisomères, dérivés marqués isotopiquement pharmaceutiquement acceptables, ainsi que des promédicaments associés. Les composés selon l'invention peuvent être des inhibiteurs de kinases (par exemple, de Janus Kinase (JAK), par exemple, de Janus kinase 2 (JAK2)). L'invention concerne également des compositions pharmaceutiques et des kits comprenant les composés selon l'invention. L'invention concerne en outre des méthodes d'utilisation des composés selon l'invention, des compositions pharmaceutiques et des kits (par exemple, pour traiter une maladie (par exemple, une maladie proliférative) chez un sujet qui en a besoin).
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