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1. WO2020097338 - METHODS OF TREATING SUBJECTS HAVING PLATELET DYSFUNCTION WITH IV MELOXICAM

Publication Number WO/2020/097338
Publication Date 14.05.2020
International Application No. PCT/US2019/060278
International Filing Date 07.11.2019
IPC
A61K 9/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61K 31/5415 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
5415ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
Applicants
  • BAUDAX BIO, INC. [US]/[US]
  • MACK, Randall J. [US]/[US]
  • MCCALLUM, Stewart [US]/[US]
Inventors
  • MACK, Randall J.
  • MCCALLUM, Stewart
Agents
  • STAKLEFF, N., Nicole
Priority Data
62/757,00307.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF TREATING SUBJECTS HAVING PLATELET DYSFUNCTION WITH IV MELOXICAM
(FR) MÉTHODES DE TRAITEMENT D'INDIVIDUS PRÉSENTANT UN DYSFONCTIONNEMENT PLAQUETTAIRE, AVEC DU MÉLOXICAM IV
Abstract
(EN)
The disclosure provides methods of treating pain in a first subject in need thereof, comprising administering meloxicam to the first subject, wherein the first subject has a platelet dysfunction. In some embodiments, a closure time of platelets isolated from the first subject before administration of meloxicam is more prolonged than a closure time of platelets isolated from an otherwise similar subject without platelet dysfunction. In some embodiments, the closure time of platelets isolated from the first subject after administration of meloxicam is comparable to a closure time of platelets isolated from the first subject before administration of meloxicam.
(FR)
L'invention concerne des méthodes de traitement de la douleur chez un premier individu le nécessitant, consistant à administrer du méloxicam au premier individu, celui-ci présentant un dysfonctionnement plaquettaire. Dans certains modes de réalisation, un temps de fermeture de plaquettes isolées à partir du premier individu avant l'administration de méloxicam est prolongé par rapport à un temps de fermeture de plaquettes isolées à partir d'un individu, autrement semblable, sans dysfonctionnement plaquettaire. Dans certains modes de réalisation, le temps de fermeture des plaquettes isolées à partir du premier individu après l'administration de méloxicam est comparable à un temps de fermeture des plaquettes isolées à partir du premier individu avant l'administration de méloxicam.
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