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1. WO2020097288 - PHAGE MIMICKING NANOPARTICLES

Publication Number WO/2020/097288
Publication Date 14.05.2020
International Application No. PCT/US2019/060202
International Filing Date 07.11.2019
IPC
A61K 9/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61K 33/242 2019.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
242Gold; Compounds thereof
A61K 33/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
38Silver; Compounds thereof
A61P 31/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
B82B 1/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
BNANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
1Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
B82Y 5/00 2011.01
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Applicants
  • UNIVERSITY OF NOTRE DAME DU LAC [US]/[US]
Inventors
  • NALLATHAMBY, Prakash Daniel
  • HOPF, Juliane
Agents
  • STRINGHAM, John C.
  • NORTON, J. Paul
Priority Data
62/757,08607.11.2018US
62/869,64802.07.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHAGE MIMICKING NANOPARTICLES
(FR) NANOPARTICULES IMITANT UN PHAGE
Abstract
(EN)
An antibacterial nanoparticle (ANP) and related methods and antibacterial medical products are disclosed. An ANP includes a silica core with a plurality of gold nanospheres conjugated thereto and at least some of the gold nanospheres being silver-coated gold nanospheres. Iron oxide nanospheres may also be conjugated to the silica core, and at least some of the silver-coated gold nanospheres, or iron oxide nanospheres, if present, can be conjugated to one or more polycationic polymers and/or one or more antibacterial peptides.
(FR)
L'invention concerne une nanoparticule antibactérienne (ANP) et des méthodes associées et des produits médicaux antibactériens. Une ANP selon l'invention comprend un noyau de silice auquel est conjuguée une pluralité de nanosphères d'or, au moins certaines des nanosphères d'or étant des nanosphères d'or revêtues d'argent. Des nanosphères d'oxyde de fer peuvent également être conjuguées au noyau de silice, et au moins une partie des nanosphères d'or revêtues d'argent, ou des nanosphères d'oxyde de fer, le cas échéant, peuvent être conjuguées à un ou plusieurs polymères polycationiques et/ou à un ou plusieurs peptides antibactériens.
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