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1. WO2020097266 - PYRIDAZINONE COMPOUNDS AND USES THEREOF

Publication Number WO/2020/097266
Publication Date 14.05.2020
International Application No. PCT/US2019/060157
International Filing Date 06.11.2019
IPC
C07D 401/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
C07D 405/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 413/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants
  • EDGEWISE THERAPEUTICS, INC. [US]/[US]
Inventors
  • HUNT, Kevin
  • KOCH, Kevin
  • RUSSELL, Alan
  • SCHLACHTER, Stephen
  • WINSHIP, Paul
  • STEELE, Chris
Agents
  • MARGULIEUX, Grant W.
Priority Data
62/756,55306.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRIDAZINONE COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS DE PYRIDAZINONE ET LEURS UTILISATIONS
Abstract
(EN)
Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, among other things, in the treating of DMD and modulating inflammatory inhibitors IL-1, IL-6 or TNF-α.
(FR)
L'invention concerne des composés de pyridazinone substitués, des conjugués, et des compositions pharmaceutiques destinés à être utilisés dans le traitement de maladies neuromusculaires, comme la dystrophie musculaire de Duchenne (DMD). Les composés selon l'invention sont utiles, entre autres, dans le traitement de la DMD et la modulation d'inhibiteurs d'IL-1, IL-6 ou TNF-α.
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