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1. WO2020097252 - COMPOSITIONS AND PRODUCTION OF RECOMBINANT AAV VIRAL VECTORS CAPABLE OF GLYCOENGINEERING IN VIVO

Publication Number WO/2020/097252
Publication Date 14.05.2020
International Application No. PCT/US2019/060142
International Filing Date 06.11.2019
IPC
C07K 16/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
A61K 39/145 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
C12N 9/24 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
24acting on glycosyl compounds (3.2)
Applicants
  • UNIVERSITY OF MIAMI [US]/[US]
Inventors
  • TERMINI, James M.
  • DESROSIERS, Ronald
Agents
  • KISSLING, Heather R.
Priority Data
62/756,23306.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND PRODUCTION OF RECOMBINANT AAV VIRAL VECTORS CAPABLE OF GLYCOENGINEERING IN VIVO
(FR) COMPOSITIONS ET PRODUCTION DE VECTEURS VIRAUX AAV RECOMBINANTS CAPABLES DE GLYCO-INGÉNIERIEE IN VIVO
Abstract
(EN)
The disclosure provides an expression vector (e.g., AAV vector) comprising a nucleic acid sequence encoding (1) the heavy and/or light chain of an antibody and (2) one or more shRNA sequences targeting fucosyltransferase-8 (FUT8).
(FR)
L'invention concerne un vecteur d'expression (par exemple, un vecteur AAV) comprenant une séquence d'acide nucléique codant pour (1) la chaîne lourde et/ou légère d'un anticorps et (2) une ou plusieurs séquences d'ARNsh ciblant la fucosyltransférase-8 (FUT8).
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