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1. WO2020097184 - PEPTIDES, COMPOSITIONS AND VACCINES FOR TREATMENT OF MICROSATELLITE INSTABILITY HYPERMUTATED TUMORS AND METHODS OF USE THEREOF

Publication Number WO/2020/097184
Publication Date 14.05.2020
International Application No. PCT/US2019/060040
International Filing Date 06.11.2019
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C12Q 1/6886 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
Applicants
  • ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US]/[US]
Inventors
  • BHARDWAJ, Nina
  • ROUDKO, Vladimir
  • BOZKUS, Cansu, Cimen
Agents
  • MACLEOD, Janet, M.
  • BARRISON, Flynn
  • GLYNN, Michael, W.
Priority Data
62/756,30506.11.2018US
62/813,82905.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PEPTIDES, COMPOSITIONS AND VACCINES FOR TREATMENT OF MICROSATELLITE INSTABILITY HYPERMUTATED TUMORS AND METHODS OF USE THEREOF
(FR) PEPTIDES, COMPOSITIONS ET VACCINS POUR LE TRAITEMENT DE TUMEURS HYPERMUTÉES À INSTABILITÉ DES MICROSATELLITES ET LEURS MÉTHODES D'UTILISATION
Abstract
(EN)
Neoantigenic peptides useful for the treatment of MSI-H tumors, vaccines and composition comprising the peptides, and methods of inducing or enhancing an immune response and of treating MSI-H tumors are provided.
(FR)
L'invention concerne des peptides néo-antigéniques utiles pour le traitement de tumeurs MSI-H, des vaccins et une composition comprenant lesdits peptides, et des méthodes d'induction ou d'amélioration d'une réponse immunitaire et de traitement de tumeurs MSI-H.
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