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1. WO2020097158 - ROCK KINASE INHIBITORS

Publication Number WO/2020/097158
Publication Date 14.05.2020
International Application No. PCT/US2019/059992
International Filing Date 06.11.2019
IPC
C07D 217/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
02with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
C07D 217/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
24Oxygen atoms
C07D 405/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants
  • CERVELLO THERAPEUTICS, LLC [US]/[US]
Inventors
  • LEE, Matthew, Randolph
  • VARANO, Anthony, Joseph
Agents
  • POLYAKOV, Mark, V.
  • MCLAUGHLIN, F., William
  • GEIMER, Stephen, D.
  • CLARK, Jeffrey, L.
  • KATZ, Martin, L.
Priority Data
62/756,20206.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ROCK KINASE INHIBITORS
(FR) INHIBITEURS DE KINASES ROCK
Abstract
(EN)
The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
(FR)
La présente invention concerne des composés qui inhibent l'activité ROCK. En particulier, la présente invention concerne des composés, des compositions pharmaceutiques et des procédés d'utilisation, tels que des procédés d'inhibition de l'activité ROCK et des procédés de traitement, par exemple du syndrome de malformation caverneuse cérébrale (CCM) et des maladies cardiovasculaires à l'aide des composés et des compositions pharmaceutiques de la présente invention.
Latest bibliographic data on file with the International Bureau