Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020097070 - MUTAGENIZED IL13 AND METHODS OF USE

Publication Number WO/2020/097070
Publication Date 14.05.2020
International Application No. PCT/US2019/059855
International Filing Date 05.11.2019
IPC
A61K 47/62 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C12N 15/88 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88using microencapsulation, e.g. using liposome vesicle
A61K 33/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
24Heavy metals; Compounds thereof
26Iron; Compounds thereof
Applicants
  • THE PENN STATE RESEARCH FOUNDATION [US]/[US]
  • TARGEPEUTICS, INC. [US]/[US]
Inventors
  • MADHANKUMAR, Achuthamangalam B.
  • CONNOR, James
  • WOLFE, Darren
Agents
  • PASSERIN, Alicia
Priority Data
62/755,98105.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MUTAGENIZED IL13 AND METHODS OF USE
(FR) IL-13 MUTAGÉNISÉE ET MÉTHODES D'UTILISATION
Abstract
(EN)
Disclosed is a conjugated mutagenized IL13, comprising a mutagenized IL13 (mIL13) conjugated to a conjugatable agent. Also disclosed is an extracellular vesicle complex, comprising an extracellular vesicle complexed with a conjugated mutagenized IL13. Also disclosed are methods of detecting an IL13-specific receptor in a sample, comprising contacting a portion of a sample with a conjugated mutagenized IL13 (mIL13) or an extracellular vesicle complex. Also disclosed are methods for diagnosing cancer in a subject, comprising administering a conjugated mutagenized IL13 or an extracellular complex, and diagnosing the subject with cancer when a level of conjugated mIL13 binding to a target of the subject is detected. Also disclosed are kits comprising a conjugated mutagenized IL 13 or an extracellular complex.
(FR)
L'invention concerne une IL-13 mutagénisée conjuguée, comprenant une IL-13 mutagénisée (mIL-13) conjuguée à un agent conjugable. L'invention concerne également un complexe de vésicule extracellulaire, comprenant une vésicule extracellulaire complexée avec une IL-13 mutagénisée conjuguée. L'invention concerne également des méthodes de détection d'un récepteur spécifique à l'IL-13 dans un échantillon, consistant à mettre en contact une partie d'un échantillon avec l'IL-13 mutagénisée conjuguée (mIL-13) ou un complexe de vésicule extracellulaire. L'invention concerne également des méthodes de diagnostic du cancer chez un sujet, consistant à administrer une IL-13 mutagénisée conjuguée ou un complexe extracellulaire et à diagnostiquer un cancer chez le sujet lorsqu'un niveau de liaison de la mIL-13 conjuguée à une cible du sujet est détecté. L'invention concerne également des kits comprenant une IL-13 mutagénisée conjuguée ou un complexe extracellulaire.
Latest bibliographic data on file with the International Bureau