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1. WO2020096394 - METHOD, KIT, AND PCR DEVICE FOR DETECTING METHYLATION OF GENE USING REDUCTION PROBE

Publication Number WO/2020/096394
Publication Date 14.05.2020
International Application No. PCT/KR2019/015112
International Filing Date 08.11.2019
IPC
C12Q 1/686 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction
C12Q 1/6886 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
CPC
C12Q 1/686
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6844Nucleic acid amplification reactions
686Polymerase chain reaction [PCR]
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2525/107
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2525Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
10Modifications characterised by
107incorporating a peptide nucleic acid
C12Q 2527/107
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2527Reactions demanding special reaction conditions
107Temperature of melting, i.e. Tm
C12Q 2531/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2531Reactions of nucleic acids characterised by
10the purpose being amplify/increase the copy number of target nucleic acid
113PCR
C12Q 2537/164
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2537Reactions characterised by the reaction format or use of a specific feature
10the purpose or use of
164Methylation detection other then bisulfite or methylation sensitive restriction endonucleases
Applicants
  • 주식회사 시선바이오머티리얼스 SEASUN BIOMATERIALS [KR]/[KR]
Inventors
  • 친바야바트 어칠 CHINBAYAR, Bat Ochir
  • 윤경주 YOON, Kyung Ju
  • 전미향 JEON, Mee Hyang
  • 이한우 LEE, Han Woo
  • 박희경 PARK, Hee Kyung
Agents
  • 특허법인 플러스 PLUS INTERNATIONAL IP LAW FIRM
Priority Data
10-2018-013704209.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) METHOD, KIT, AND PCR DEVICE FOR DETECTING METHYLATION OF GENE USING REDUCTION PROBE
(FR) PROCÉDÉ, KIT ET DISPOSITIF D'ACP POUR LA DÉTECTION DE MÉTHYLATION D'UN GÈNE À L'AIDE D'UNE SONDE DE RÉDUCTION
(KO) 리덕션 프로브를 이용한 유전자의 메틸화 검출 방법, 검출 키트 및 PCR 장치
Abstract
(EN)
The present invention relates to a method, a kit, and a PCR device for detecting methylation of a gene using a reduction probe, which can detect methylation of a gene without treating bisulfite or a methylation-specific enzyme, and thus is simple and has high sensitivity and accuracy in detection, and thus is useful in fields for diagnosing various diseases including cancer.
(FR)
La présente invention concerne un procédé, un kit et un dispositif d'ACP pour détecter la méthylation d'un gène à l'aide d'une sonde de réduction qui peut détecter la méthylation d'un gène sans traiter le bisulfite ou une enzyme spécifique à la méthylation. Elle est ainsi simple et présente une sensibilité et une précision élevées dans la détection et est donc utile dans des domaines pour diagnostiquer diverses maladies, y compris le cancer.
(KO)
본 발명은 리덕션 프로브를 이용한 유전자의 메틸화 검출 방법, 검출 키트 및 PCR 장치에 관한 것으로서, 바이설파이트 또는 메틸화 특이적 효소를 처리하지 않고도 유전자의 메틸화를 검출할 수 있어 간편하고, 우수한 민감도 및 정확도로 검출할 수 있어 암을 포함한 다양한 질병 진단 분야에서 유용하다.
Also published as
Latest bibliographic data on file with the International Bureau