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1. WO2020096281 - ALGINIC ACID-BASED INJECTABLE HYDROGEL SYSTEM

Publication Number WO/2020/096281
Publication Date 14.05.2020
International Application No. PCT/KR2019/014682
International Filing Date 01.11.2019
IPC
A61K 49/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
A61K 49/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
A61K 9/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor
A61K 47/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants
  • 국립암센터 NATIONAL CANCER CENTER [KR]/[KR]
Inventors
  • 최용두 CHOI, Yong Doo
  • 이선숙 LEE, Seon Sook
  • 김현진 KIM, Hyun Jin
  • 손대경 SOHN, Dae Kyung
  • 김석기 KIM, Seok Ki
  • 김영우 KIM, Young Woo
  • 류근원 RYU, Keun Won
  • 윤홍만 YOON, Hong Man
Agents
  • 특허법인(유)화우 YOON & YANG (IP) LLC
Priority Data
10-2018-013516106.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) ALGINIC ACID-BASED INJECTABLE HYDROGEL SYSTEM
(FR) SYSTÈME D'HYDROGEL INJECTABLE À BASE D'ACIDE ALGINIQUE
(KO) 알긴산 기반의 주입형 수화젤 시스템
Abstract
(EN)
The present invention provides an alginic acid-based injectable hydrogel system for labeling an accurate position of a disease lesion and effectively delivering a drug to a target region. The formulation of the present invention can make it easy to locally inject a contrast medium and a drug into a target region while controlling the release rate of the contrast medium or the drug, with the formation of the hydrogel in the injected region. Through the advantages, the labeled position can be accurately determined from images, thereby enhancing the precision of surgical operation, with a minimal incision formed therefor. In addition, when used, the alginic acid-based injectable hydrogel system allows the effective local delivery of a drug to a target region while increasing the long-acting effect of the drug.
(FR)
La présente invention concerne un système d'hydrogel injectable à base d'acide alginique pour marquer une position précise d'une lésion pathologique et administrer efficacement un médicament à une région cible. La formulation de la présente invention peut permettre d'injecter facilement un produit de contraste et un médicament localement dans une région cible tout en régulant le taux de libération du produit de contraste ou du médicament, avec formation de l'hydrogel dans la région injectée. Grâce aux avantages, la position marquée peut être déterminée avec précision à partir d'images, ce qui permet d'améliorer la précision de l'intervention chirurgicale, avec une incision minimale formée à cet effet. De plus, lorsqu'il est utilisé, le système d'hydrogel injectable à base d'acide alginique permet l'administration locale efficace d'un médicament dans une région cible tout en augmentant l'effet d'action prolongée du médicament.
(KO)
본 발명은 질병 병변의 정확한 위치표지 및 표적 부위에서의 효과적 약물 전달을 위한 알긴산 기반의 주입형 수화젤 시스템을 제공한다. 본 발명의 제제는 표적 부위에서 영상 조영제 및 약물의 국소적 주입을 용이하게 하는 동시에, 주입된 부위에서 수화젤이 형성되면서 영상 조영제 또는 약물의 방출 속도를 조절할 수 있다. 이를 통하여, 표지된 위치를 영상으로부터 정확히 식별하여 수술의 정확도를 향상시키고 최소 절개가 가능하게 할 수 있다. 또한, 알긴산 기반의 주입형 수화젤 시스템을 이용하면, 효과적으로 표적 부위에 국소적으로 약물을 전달하면서 약물 지속 효과를 증가시킬 수 있다.
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