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1. WO2020096234 - COMPOSITION FOR PREVENTING OR TREATING ATOPIC DERMATITIS COMPRISING SKIN-PENETRATING NUCLEIC ACID COMPLEX AS EFFECTIVE COMPONENT

Publication Number WO/2020/096234
Publication Date 14.05.2020
International Application No. PCT/KR2019/013970
International Filing Date 23.10.2019
IPC
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 47/54 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
A61K 31/7088 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61P 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61K 8/60 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
60Sugars; Derivatives thereof
Applicants
  • 주식회사 시선테라퓨틱스 SEASUN THERAPEUTICS [KR]/[KR]
Inventors
  • 유지연 YU, Ji-Yeon
  • 김혜주 KIM, Hye Joo
  • 강유선 KANG, Yusun
  • 이동인 LEE, Dong In
  • 박희경 PARK, Hee Kyung
Agents
  • 이처영 LEE, Cheo Young
  • 장제환 CHANG, Je Hwan
Priority Data
10-2018-013589207.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR PREVENTING OR TREATING ATOPIC DERMATITIS COMPRISING SKIN-PENETRATING NUCLEIC ACID COMPLEX AS EFFECTIVE COMPONENT
(FR) COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT DE LA DERMATITE ATOPIQUE COMPRENANT UN COMPLEXE D'ACIDE NUCLÉIQUE PÉNÉTRANT DANS LA PEAU EN TANT QUE PRINCIPE ACTIF
(KO) 피부 투과성 핵산 복합체를 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 조성물
Abstract
(EN)
The present invention relates to a composition for preventing or treating skin diseases, comprising a skin-penetrating nucleic acid complex as an effective component, and more specifically, to a pharmaceutical composition or a cosmetic composition for preventing, alleviating, or treating atopic dermatitis, comprising a skin-penetrating nucleic acid complex in which a carrier peptide nucleic acid and a bioactive nucleic acid targeting TLR2 or IL-4Rα are connected by complementary binding. The skin-penetrating nucleic acid complex according to the present invention, in which the carrier peptide nucleic acid and the bioactive nucleic acid targeting TLR2 or IL-4Rα are connected by complementary binding, has high skin permeationand skin retention, and thus is useful in the prevention, alleviation or treatment of skin diseases such as atopic dermatitis.
(FR)
La présente invention concerne une composition pour prévenir ou traiter des maladies cutanées, comprenant un complexe d'acide nucléique pénétrant dans la peau en tant que principe actif, et, plus spécifiquement, une composition pharmaceutique ou une composition cosmétique pour prévenir, soulager ou traiter la dermatite atopique, comprenant un complexe d'acide nucléique pénétrant dans la peau dans lequel un acide nucléique peptidique porteur et un acide nucléique bioactif ciblant TLR2 ou IL-4Rα sont reliés par liaison complémentaire. Le complexe d'acide nucléique pénétrant dans la peau selon la présente invention, dans lequel l'acide nucléique peptidique porteur et l'acide nucléique bioactif ciblant TLR2 ou IL-4Rα sont reliés par liaison complémentaire, a une perméabilité cutanée et une rétention cutanée élevées, et est par conséquent utile dans la prévention, le soulagement ou le traitement de maladies cutanées telles que la dermatite atopique.
(KO)
본 발명은 피부 투과성 핵산 복합체를 유효성분으로 함유하는 피부질환의 예방 또는 치료용 조성물에 관한 것으로, 더욱 자세하게는 TLR2 또는 IL-4Rα을 표적하는 생활성 핵산과 캐리어 펩티드 핵산이 상보적으로 결합된 피부 투과성 핵산 복합체를 함유하는 아토피 피부염의 예방, 개선 또는 치료용 약학 조성물 또는 화장료 조성물에 관한 것이다. 본 발명에 따른 TLR2 또는 IL-4Rα을 표적하는 생활성 핵산과 캐리어 펩티드 핵산이 상보적으로 결합된 피부 투과성 핵산 복합체는 피부 투과성 및 피부 잔류성이 높아 아토피성 피부염과 같은 피부질환의 예방, 개선 또는 치료에 유용하다.
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