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1. WO2020095880 - TIGHT JUNCTION MODULATOR, ABSORPTION PROMOTER OF COMPOUND COMPRISING MODULATOR, AND PHARMACEUTICAL COMPOSITION, QUASI-DRUG COMPOSITION, COSMETIC COMPOSITION, AND FOOD COMPOSITION COMPRISING MODULATOR AS ACTIVE INGREDIENT

Publication Number WO/2020/095880
Publication Date 14.05.2020
International Application No. PCT/JP2019/043215
International Filing Date 05.11.2019
IPC
A61K 31/196 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
196the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/352 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/405 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
404Indoles, e.g. pindolol
405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
A61K 31/7048 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
A23L 33/10 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
Applicants
  • 国立大学法人名古屋大学 NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY [JP]/[JP]
Inventors
  • 廣明 秀一 HIROAKI Hidekazu
  • 天野 剛志 TENNO Takeshi
  • 久田 美咲 HISADA Misaki
Agents
  • 松本 征二 MATSUMOTO Seiji
Priority Data
2018-20938307.11.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) TIGHT JUNCTION MODULATOR, ABSORPTION PROMOTER OF COMPOUND COMPRISING MODULATOR, AND PHARMACEUTICAL COMPOSITION, QUASI-DRUG COMPOSITION, COSMETIC COMPOSITION, AND FOOD COMPOSITION COMPRISING MODULATOR AS ACTIVE INGREDIENT
(FR) MODULATEUR À JONCTION SERRÉE, PROMOTEUR D'ABSORPTION DE COMPOSÉ COMPRENANT UN MODULATEUR, ET COMPOSITION PHARMACEUTIQUE, COMPOSITION DE QUASI-MÉDICAMENT, COMPOSITION COSMÉTIQUE, ET COMPOSITION ALIMENTAIRE COMPRENANT UN MODULATEUR EN TANT QUE PRINCIPE ACTIF
(JA) タイトジャンクションの緩和剤、該緩和剤を含む化合物の吸収促進剤、並びに、該緩和剤を有効成分として含む医薬組成物、医薬部外品組成物、化粧品組成物および食品組成物
Abstract
(EN)
The present invention addresses the problem of providing a tight junction modulator that comprises a compound which is already on the market as a medicine or is already used as a quasi-drug or the like and which modulates tight junctions. This problem can be solved by a tight junction modulator which comprises at least one selected from the compounds represented by formulas (1) to (4) and at least one selected from pharmaceutically acceptable salts of the compounds represented by formulas (1) to (4). [Chem. 1]
(FR)
Le problème à résoudre par la présente invention concerne la fourniture d'un modulateur à jonction serrée comprenant un composé qui est déjà sur le marché en tant que médicament ou qui est déjà utilisé en tant que quasi-médicament ou similaire et qui module des jonctions serrées. La solution selon la présente invention porte sur un modulateur à jonction serrée qui comprend au moins un composé choisi parmi les composés représentés par les formules (1) à (4) et au moins l'un choisi parmi les sels pharmaceutiquement acceptables des composés représentés par les formules (1) à (4). [Chem. 1]
(JA)
既に医薬品として上市済み、或いは、医薬部外品等で既に使用されている化合物で、タイトジャンクションを緩和する化合物を含むタイトジャンクションの緩和剤を提供することを課題とする。 下記式(1)乃至(4)で表される化合物から選択される少なくとも1種、または、 下記式(1)乃至(4)で表される化合物の薬学的に許容される塩から選択される少なくとも1種、 を含む、タイトジャンクションの緩和剤により課題を解決できる。 【化1】
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