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1. WO2020095405 - SUBSTRATE FOR BIOMOLECULE ANALYSIS, FLOW CELL FOR BIOMOLECULE ANALYSIS, AND METHOD FOR BIOMOLECULE ANALYSIS

Publication Number WO/2020/095405
Publication Date 14.05.2020
International Application No. PCT/JP2018/041474
International Filing Date 08.11.2018
Chapter 2 Demand Filed 23.08.2019
IPC
C12M 1/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
C12Q 1/68 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
G01N 37/00 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
37Details not covered by any other group of this subclass
CPC
C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
1Apparatus for enzymology or microbiology
C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
G01N 37/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
37Details not covered by any other group of this subclass
Applicants
  • 株式会社日立ハイテク HITACHI HIGH-TECH CORPORATION [JP]/[JP]
Inventors
  • 板橋 直志 ITABASHI Naoshi
  • 奈良原 正俊 NARAHARA Masatoshi
  • 横山 徹 YOKOYAMA Toru
Agents
  • 特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES
Priority Data
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) SUBSTRATE FOR BIOMOLECULE ANALYSIS, FLOW CELL FOR BIOMOLECULE ANALYSIS, AND METHOD FOR BIOMOLECULE ANALYSIS
(FR) SUBSTRAT POUR ANALYSE DE BIOMOLÉCULES, SYSTÈME DE CYTOMÉTRIE EN FLUX POUR ANALYSE DE BIOMOLÉCULES ET PROCÉDÉ D'ANALYSE DE BIOMOLÉCULES
(JA) 生体分子分析用基板、生体分子分析用フローセル、及び生体分子解析方法
Abstract
(EN)
In order to enhance throughput in biomolecule analysis, the present invention provides: a substrate which can be positioned, and on which a high-density spot pattern is arranged; a flow cell which uses the substrate; and an analysis method which uses the substrate. In order to realize the above invention, in the present disclosure, a substrate for biomolecule analysis is used in which a pattern of spots to which a biomolecule adheres is provided on the surface of a substrate, and a region of the surface of the substrate is provided with a first region having a first optical characteristic, and a second region having a second optical characteristic (Fig. 18).
(FR)
L'invention a pour objet d'améliorer le rendement dans l'analyse de biomolécules en fournissant un substrat pouvant être placé, et comportant un motif de points à haute densité; un système de cytométrie en flux utilisant le substrat; et un procédé d'analyse utilisant le substrat. La solution selon l'invention porte sur l'utilisation d'un substrat permettant l'analyse de biomolécules. Ledit substrat comportant sur sa surface un motif de points auxquels une biomolécule adhère, et une région de la surface du substrat est pourvue d'une première région ayant une première caractéristique optique, et d'une seconde région ayant une seconde caractéristique optique (Fig. 18).
(JA)
生体分子分析のスループット向上を図るため、位置合わせが可能かつ、高密度なスポットパターンを配置した基板、これを用いたフローセル、これを用いた解析方法を提供する。これを実現するため、本開示では、基板の表面に、生体分子が付着するスポットのパターンを備え、基板の表面の領域には第一の光学特性を有する第一の領域と第二の光学特性を有する第二の領域を備えた生体分子分析用基板を用いる(図18)。
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