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1. WO2020095052 - PORE

Publication Number WO/2020/095052
Publication Date 14.05.2020
International Application No. PCT/GB2019/053153
International Filing Date 07.11.2019
IPC
C12Q 1/6869 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
Applicants
  • OXFORD NANOPORE TECHNOLOGIES LIMITED [GB]/[GB]
  • VIB VZW [BE]/[BE]
  • VRIJE UNIVERITEIT BRUSSEL [BE]/[BE]
Inventors
  • REMAUT, Han
  • VAN DER VERREN, Sander, Egbert
  • VAN GERVEN, Nani
  • JAYASINGHE, Lakmal, Nishantha
  • WALLACE, Elizabeth Jayne
  • SINGH, Pratik, Raj
  • HAMBLEY, Richard, George
  • JORDAN, Michael, Robert
  • KILGOUR, John, Joseph
  • HERON, Andre, John
Agents
  • J A KEMP LLP
Priority Data
1818216.208.11.2018GB
1819054.622.11.2018GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PORE
(FR) PORE
Abstract
(EN)
A system for characterising a target polynucleotide, the system comprising a membrane and a pore complex; wherein the pore complex comprises: (i) a nanopore located in the membrane, and (ii) an auxiliary protein or peptide attached to the nanopore; wherein the nanopore and the auxiliary protein or peptide together form a continuous channel across the membrane, the channel comprising a first constriction region and a second constriction region; wherein the first constriction region is formed by a portion of the nanopore, and wherein the second constriction region is formed by at least a portion of the auxiliary protein or peptide.
(FR)
Système de caractérisation d'un polynucléotide, le système comprenant une membrane et un complexe de pores; le complexe de pores comprenant : (I) un nanopore situé dans la membrane, et (ii) une protéine ou un peptide auxiliaire fixé au nanopore; le nanopore et la protéine ou le peptide auxiliaire formant ensemble un canal continu à travers la membrane, le canal comprenant une première région de constriction et une seconde région de constriction; la première région de constriction étant formée par une partie du nanopore, et la seconde région de constriction étant formée par au moins une partie de la protéine ou du peptide auxiliaire.
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