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1. WO2020094827 - MICROFLUIDIC DROPLET CONCENTRATOR

Publication Number WO/2020/094827
Publication Date 14.05.2020
International Application No. PCT/EP2019/080643
International Filing Date 08.11.2019
IPC
B01L 3/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01L 3/02 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
02Burettes; Pipettes
CPC
B01L 2200/0673
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
06Fluid handling related problems
0673Handling of plugs of fluid surrounded by immiscible fluid
B01L 2300/0663
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
06Auxiliary integrated devices, integrated components
0627Sensor or part of a sensor is integrated
0663Whole sensors
B01L 2300/0829
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
08Geometry, shape and general structure
0809rectangular shaped
0829Multi-well plates; Microtitration plates
B01L 2300/0851
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
08Geometry, shape and general structure
0848Specific forms of parts of containers
0851Bottom walls
B01L 2300/0864
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
08Geometry, shape and general structure
0861Configuration of multiple channels and/or chambers in a single devices
0864comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
B01L 2400/0469
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2400Moving or stopping fluids
04Moving fluids with specific forces or mechanical means
0403specific forces
0469Buoyancy
Applicants
  • ETH ZURICH [CH]/[CH]
Inventors
  • AROSIO, Paolo
  • KOPP, Marie
Priority Data
18205353.809.11.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MICROFLUIDIC DROPLET CONCENTRATOR
(FR) CONCENTRATEUR DE GOUTTELETTES MICROFLUIDIQUES
Abstract
(EN)
In a method of increasing a concentration of an analyte in a sample fluid, a stream of droplets of the sample fluid is created, the droplets being separated by a carrier fluid. The stream of droplets is moved through a flow channel (20). The flow channel has sufficiently small dimensions to cause the droplets to be deformed from spherical shape when they move through the flow channel. Droplets are captured from the stream in a plurality of traps (21). The traps have dimensions that are sufficiently large to allow the captured droplets to assume essentially spherical shape. The traps are arranged above or below the flow channel with respect to the vertical direction in such a manner that buoyancy acts to keep the captured droplets in the traps. While the droplets remain captured in the traps by their buoyancy, they are allowed to shrink by absorption of solvent from the captured droplets into the carrier fluid, thereby increasing the concentration of the analyte in the captured droplets. The method can be used for the detection of analytes in the eluate of a fractionation method like HPLC.
(FR)
Dans un procédé d'augmentation de la concentration d'un analyte dans un fluide échantillon, un flux de gouttelettes du fluide échantillon est créé, les gouttelettes étant séparées par un fluide porteur. Le flux de gouttelettes est déplacé à travers un canal d'écoulement (20). Le canal d'écoulement comprend des dimensions suffisamment petites pour amener la déformation des gouttelettes de forme sphérique lorsqu'elles se déplacent à travers le canal d'écoulement. Des gouttelettes sont capturées à partir du flux dans une pluralité de pièges (21). Les pièges comprennent des dimensions qui sont suffisamment grandes pour permettre aux gouttelettes capturées de prendre une forme essentiellement sphérique. Les pièges sont agencés au-dessus ou au-dessous du canal d'écoulement par rapport à la direction verticale de sorte que la flottabilité agit pour maintenir les gouttelettes capturées dans les pièges. Tandis que les gouttelettes restent capturées dans les pièges par leur flottabilité, elles peuvent se rétracter par absorption de solvant à partir des gouttelettes capturées dans le fluide porteur, ce qui permet d'augmenter la concentration de l'analyte dans les gouttelettes capturées. Le procédé peut être utilisé pour la détection d'analytes dans l'éluat d'un procédé de fractionnement comme la HPLC.
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