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1. WO2020094743 - A REAL-TIME CONTINUOUS GLUCOSE MONITORING BASED METHOD TO TRIGGER CARBOHYDRATES ASSUMPTION TO PREVENT/MITIGATE HYPOGLYCEMIC EVENTS

Publication Number WO/2020/094743
Publication Date 14.05.2020
International Application No. PCT/EP2019/080444
International Filing Date 06.11.2019
IPC
G16H 20/17 2018.01
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
20ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
10relating to drugs or medications, e.g. for ensuring correct administration to patients
17delivered via infusion or injection
G16H 50/20 2018.01
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
20for computer-aided diagnosis, e.g. based on medical expert systems
CPC
G16H 20/17
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
20ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
10relating to drugs or medications, e.g. for ensuring correct administration to patients
17delivered via infusion or injection
G16H 50/20
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
20for computer-aided diagnosis, e.g. based on medical expert systems
Applicants
  • UNIVERSITA' DEGLI STUDI DI PADOVA [IT]/[IT]
Inventors
  • SPARACINO, Giovanni
  • CAMERLINGO, Nunzio
  • VETTORETTI, Martina
  • FACCHINETTI, Andrea
  • DEL FAVERO, Simone
  • CAPPON, Giacomo
Agents
  • SAVI, Massimiliano
  • GERVASI, Gemma
  • PALLINI GERVASI, Diego
  • CATTANEO, Elisabetta
  • PALLADINO, Massimo
  • VALENZA, Silvia
  • ZACCARO, Elisabetta
  • COPPO, Alessandro
  • CELONA, Antonio
  • TORTI, Carlo Maria Emilio
  • CINQUANTINI, Bruno
  • CONTADIN, Giorgio
  • MASALA, Gian Tomaso
  • GIRALDI, Elisa
Priority Data
62/756,22706.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A REAL-TIME CONTINUOUS GLUCOSE MONITORING BASED METHOD TO TRIGGER CARBOHYDRATES ASSUMPTION TO PREVENT/MITIGATE HYPOGLYCEMIC EVENTS
(FR) PROCÉDÉ BASÉ SUR LA SURVEILLANCE CONTINUE EN TEMPS RÉEL DU GLUCOSE POUR DÉCLENCHER UNE SUPPOSITION D'HYDRATES DE CARBONE EN VUE DE PRÉVENIR/ATTÉNUER DES ÉVÉNEMENTS HYPOGLYCÉMIQUES
Abstract
(EN)
Mitigation of the risk of prolonged hypoglycemia in T1D management requires patient to assume a small dose of fast-acting carbohydrates, called hypotreatment (HT), as soon as hypoglycemia is detected. This invention consists in a method that, on the basis of the datastream generated by a continuous glucose monitoring (CGM) sensor, triggers the assumption of preventive HTs i.e., snacks that, being quickly absorbed into the circulation, avoid, or at least mitigate, a forthcoming hypoglycemic event. The method resorts to the "dynamic risk" (DR) non-linear function, which combines current glycemia with its rate-of-change provided by CGM, adapted to distinguish the severity of the about-to-happen hypoglycemia. The method has been tested in a simulated realistic scenario. Results show that the administration of an HT in advance, as triggered by the new method, brings to a strong reduction of the time that a patient would have spent in hypoglycemia assuming the HT at hypoglycemic threshold crossing.
(FR)
L'invention aborde de problème de l'atténuation du risque d'hypoglycémie prolongée dans la prise en charge du T1D qui exige que le patient prenne une petite dose d'hydrates de carbone à action rapide, appelé hypotraitement (HT), dès qu'une hypoglycémie est détectée. La solution selon la présente invention porte sur un procédé qui, sur la base du flux de données généré par un capteur de surveillance continue du glucose (CGM), déclenche la prise de HT préventifs, c'est-à-dire des en-cas qui, étant rapidement absorbés dans la circulation, évitent ou au moins atténuent un événement hypoglycémique prochain. Le procédé fait appel à la fonction non linéaire du "risque dynamique" (DR), qui combine la glycémie actuelle avec son taux de variation fourni par la CGM, adaptée pour distinguer la gravité de l'hypoglycémie qui est sur le point de se produire. Le procédé a été testé dans un scénario réaliste simulé. Les résultats montrent que l'administration à l'avance d'un HT, tel que déclenché par le nouveau procédé, apporte une forte réduction du temps qu'un patient aurait passé en situation d'hypoglycémie en prenant le HT au franchissement du seuil hypoglycémique.
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