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1. WO2020093990 - ANTI-TNFα/ANTI IL‐17A NATURAL ANTIBODY STRUCTURE-LIKE HETERODIMER FORM OF BISPECIFIC ANTIBODY AND PREPARATION METHOD THEREFOR

Publication Number WO/2020/093990
Publication Date 14.05.2020
International Application No. PCT/CN2019/115587
International Filing Date 05.11.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
C07K 16/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
32against translation products from oncogenes
C07K 16/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C07K 14/54 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
C12N 15/13 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
Applicants
  • 北京韩美药品有限公司 BEIJING HANMI PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 刘家望 LIU, Jiawang
  • 杨亚平 YANG, Yaping
  • 宋楠萌 SONG, Nanmeng
  • 肖文楚 XIAO, Wenchu
  • 郑哲雄 CHUNG, Chulwoong
  • 金孟燮 KIM, Maengsup
Agents
  • 北京律智知识产权代理有限公司 BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD.
Priority Data
201811307673.605.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ANTI-TNFα/ANTI IL‐17A NATURAL ANTIBODY STRUCTURE-LIKE HETERODIMER FORM OF BISPECIFIC ANTIBODY AND PREPARATION METHOD THEREFOR
(FR) FORME HÉTÉRODIMÈRE D'UN ANTICORPS BISPÉCIFIQUE DE TYPE À STRUCTURE D'ANTICORPS NATUREL ANTI-TNFα/ANTI IL‐17A ET PROCÉDÉ DE PRÉPARATION ASSOCIÉ
(ZH) 抗TNFα/抗IL‐17A天然抗体结构样异源二聚体形式双特异抗体及其制备
Abstract
(EN)
Provided are an anti-TNFα/anti IL-17A natural antibody structure-like heterodimer form of a bispecific antibody and a preparation method therefor, wherein the antibody can bind two target molecules simultaneously, and can be used for treating complex diseases.
(FR)
L'invention concerne une forme hétérodimère d'un anticorps bispécifique de type à structure d'anticorps naturel anti-TNFα/anti IL-17A et son procédé de préparation, l'anticorps pouvant se lier simultanément à deux molécules cibles, et pouvant être utilisé pour traiter des maladies complexes.
(ZH)
提供一种抗TNFα/抗IL-17A天然抗体结构样异源二聚体形式双特异抗体及其制备,所述抗体能同时结合两种靶分子,可治疗复杂疾病。
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