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1. WO2020093739 - CARBON NANOTUBE COMPOSITE CARRIER HAVING SYNERGISTIC EFFECT OF PHOTOTHERMAL THERAPY AND GENE THERAPY, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Publication Number WO/2020/093739
Publication Date 14.05.2020
International Application No. PCT/CN2019/098652
International Filing Date 31.07.2019
IPC
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 41/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 47/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
04Non-metals; Compounds thereof
A61K 47/42 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
A61K 31/05 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/352 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
CPC
A61K 31/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/7024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7024Esters of saccharides
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
A61K 31/7088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 41/0052
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0052Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
Applicants
  • 大连民族大学 DALIAN MINZU UNIVERSITY [CN]/[CN]
Inventors
  • 张树彪 ZHANG, Shubiao
  • 赵轶男 ZHAO, Yinan
  • 曹英楠 CAO, Yingnan
  • 周泉 ZHOU, Quan
  • 崔韶晖 CUI, Shaohui
  • 支德福 ZHI, Defu
  • 陈会英 CHEN, Huiying
Agents
  • 大连智高专利事务所(特殊普通合伙) DALIAN CHICCO PATENT OFFICE
Priority Data
201811314938.506.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CARBON NANOTUBE COMPOSITE CARRIER HAVING SYNERGISTIC EFFECT OF PHOTOTHERMAL THERAPY AND GENE THERAPY, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
(FR) SUPPORT COMPOSITE DE NANOTUBES DE CARBONE AYANT UN EFFET SYNERGIQUE DE THÉRAPIE PHOTOTHERMIQUE ET DE THÉRAPIE GÉNIQUE, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION
(ZH) 光热治疗与基因治疗协同增效作用的碳纳米管复合载体及其制备方法与应用
Abstract
(EN)
A carbon nanotube composite carrier having a synergistic effect of photothermal therapy and gene therapy, a preparation method therefor and an application thereof. The carrier is composed of a carrier portion and a gene, the carrier portion comprising carbon nanotubes, peptide lipids and/or auxiliaries. A method of self-assembly is used to fix a modifier to the carbon nanotubes to obtain a composite carrier that may carry and transport a gene. The described composite carrier overcomes the problems with pure carbon nanotubes wherein water solubility is poor, biocompatibility is low, and efficiency in carrying and transporting genes is poor. At the same time, the described composite carrier has higher photothermal conversion performance and gene transport efficiency, the cytotoxicity of carbon nanotubes is reduced, and the problem of the localized accumulation of carbon nanotubes is alleviated. The synergistic effect of photothermal therapy and gene therapy is used to solve the problem in tumor treatment wherein the efficacy of a single treatment method is poor.
(FR)
L'invention concerne un support composite de nanotubes de carbone ayant un effet synergique de thérapie photothermique et de thérapie génique, son procédé de préparation et son application. Le support est composé d'une partie porteuse et d'un gène, la partie porteuse comprenant des nanotubes de carbone, des lipides peptidiques et/ou des auxiliaires. Un procédé d'autoassemblage est utilisé pour fixer un modificateur aux nanotubes de carbone afin d'obtenir un support composite qui peut porter et transporter un gène. Le support composite décrit résout les problèmes posés par les nanotubes de carbone purs dans lesquels la solubilité dans l'eau est faible, la biocompatibilité est faible et l'efficacité dans le support et le transport des gènes est médiocre. Parallèlement, le support composite décrit présente une performance de conversion photothermique et une efficacité de transport de gène supérieures, la cytotoxicité des nanotubes de carbone est réduite, et le problème de l'accumulation localisée de nanotubes de carbone est atténué. L'effet synergique d'une thérapie photothermique et d'une thérapie génique est utilisé pour résoudre le problème de traitement de tumeur dans lequel l'efficacité d'un procédé de traitement unique est médiocre.
(ZH)
一种光热治疗和基因治疗协同增效作用的碳纳米管复合载体及其制备方法与应用。由载体部分和基因组成,所述载体部分包括碳纳米管、肽脂质和/或助剂。采用自组装的方法将修饰剂固定于碳纳米管,制得可携带和转运基因的复合载体。该复合载体克服了单纯碳纳米管水溶性差、生物相容性低、携带和转运基因效率不佳的问题,同时具备更高的光热转换性能和基因转运效率,并降低了碳纳米管的细胞毒性,缓解了碳纳米管局部蓄积的问题。利用光热治疗与基因治疗协同增效的作用,解决了肿瘤治疗中单一治疗方法疗效差的问题。
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