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1. WO2020093272 - SULFONYL FLUORIDE-CONTAINING COMPOUND WITH HIGH AFFINITY TO PARP RECEPTOR AND PREPARATION AND USE THEREOF

Publication Number WO/2020/093272
Publication Date 14.05.2020
International Application No. PCT/CN2018/114371
International Filing Date 07.11.2018
IPC
C07D 237/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
237Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
26condensed with carbocyclic rings or ring systems
30Phthalazines
32with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
C07D 403/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
A61K 31/502 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50Pyridazines; Hydrogenated pyridazines
502ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 上海科技大学 SHANGHAI TECH UNIVERSITY [CN]/[CN]
Inventors
  • 杨光 YANG, Guang
  • 许红涛 XU, Hongtao
Agents
  • 上海光华专利事务所(普通合伙) J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (GENERAL PARTNERSHIP)
Priority Data
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) SULFONYL FLUORIDE-CONTAINING COMPOUND WITH HIGH AFFINITY TO PARP RECEPTOR AND PREPARATION AND USE THEREOF
(FR) COMPOSÉ CONTENANT DU FLUORURE DE SULFONYLE AYANT UNE AFFINITÉ ÉLEVÉE VIS-À-VIS DU RÉCEPTEUR PARP, PRÉPARATION ET UTILISATION ASSOCIÉES
(ZH) 一种含磺酰氟的对PARP受体具有高亲和力的化合物及其制备和用途
Abstract
(EN)
The present application belongs to the technical field of organic chemistry, and particularly relates to a sulfonyl fluoride-containing compound with high affinity to a PARP receptor, or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof. The present application provides a compound or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof, the compound having the structural formula shown in formula I. The compound provided by the present application is a novel, safe and highly efficient PARP inhibitor drug, and a positron tomography imaging agent with PARP as a biomarker, with significant social and economic value.
(FR)
La présente invention se rapporte au domaine technique de la chimie organique, et concerne en particulier un composé contenant du fluorure de sulfonyle ayant une affinité élevée vis-à-vis d'un récepteur PARP, ou un sel, un isomère, un promédicament ou un solvate pharmaceutiquement acceptable de celui-ci. La présente invention concerne un composé ou un sel, un isomère, un promédicament ou un solvate pharmaceutiquement acceptable de celui-ci, le composé ayant la formule structurale représentée par la formule I. Le composé fourni par la présente invention est un nouveau médicament inhibiteur de PARP sans danger et hautement efficace, et un agent d'imagerie par tomographie par positrons ayant PARP comme biomarqueur, qui présente une valeur socioéconomique significative.
(ZH)
本发明涉及有机化学领域,特别是涉及一种含磺酰氟的对PARP受体具有高亲和力的化合物或其药学上可接受的盐、异构体、前药或溶剂化物。本发明提供一种化合物或其药学上可接受的盐、异构体、前药或溶剂化物,所述化合物的结构式如式I所示。本发明所提供的化合物是一种更安全、高效的新型PARP抑制剂药物及以PARP为生物标志物的正电子断层显像剂,具有巨大的社会价值和经济价值。
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