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1. WO2020093159 - BROADLY-NEUTRALIZING ANTIBODY AND NEURAMINIDASE INHIBITOR COMBINATIONS TO PREVENT OR TREAT INFLUENZA VIRUS INFECTIONS

Publication Number WO/2020/093159
Publication Date 14.05.2020
International Application No. PCT/CA2019/051582
International Filing Date 06.11.2019
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 31/215 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 39/42 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42viral
A61P 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
C07C 233/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
52with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
Applicants
  • MCMASTER UNIVERSITY [CA]/[CA]
Inventors
  • MILLER, Matthew
  • ZHANG, Ali
Agents
  • BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.
Priority Data
62/756,33506.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BROADLY-NEUTRALIZING ANTIBODY AND NEURAMINIDASE INHIBITOR COMBINATIONS TO PREVENT OR TREAT INFLUENZA VIRUS INFECTIONS
(FR) ASSOCIATIONS D'ANTICORPS NEUTRALISANTS À LARGE SPECTRE ET D'INHIBITEURS DE LA NEURAMINIDASE POUR PRÉVENIR OU TRAITER DES INFECTIONS À VIRUS INFLUENZA
Abstract
(EN)
The present application relates to methods and compositions for preventing or treating influenza virus infections. In particular, the present application relates to the use of one or more broadly-neutralizing antibodies (bNAbs) in combination with one or more neuraminidase inhibitors such as oseltamivir for the prevention or treatment of influenza infections. In particular, the one or more broadly-neutralizing antibodies bind to the stalk domain of hemagglutinin (HA).
(FR)
La présente invention concerne des méthodes et des compositions pharmaceutiques pour la prévention et le traitement d'infections à virus Influenza. En particulier, la présente invention concerne l'utilisation d'un ou de plusieurs anticorps neutralisants à large spectre (bNAB, pour "broadly-neutralizing antibodies") en association avec un ou plusieurs inhibiteurs de la neuraminidase tels que l'oseltamivir pour la prévention ou le traitement d'infections à Influenza. En particulier, le ou les anticorps neutralisants à large spectre se lient au domaine tige de l'hémagglutinine (HA).
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