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1. WO2020093055 - PEPTIDE LIBRARIES WITH NON-CANONICAL AMINO ACIDS

Publication Number WO/2020/093055
Publication Date 07.05.2020
International Application No. PCT/US2019/059690
International Filing Date 04.11.2019
IPC
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
CPC
A61K 49/0002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0002General or multifunctional contrast agents, e.g. chelated agents
A61K 49/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
14Peptides, e.g. proteins
A61K 51/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
C12N 15/1072
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
1034Isolating an individual clone by screening libraries
1072Differential gene expression library synthesis, e.g. subtracted libraries, differential screening
G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
Applicants
  • INDI MOLECULAR, INC. [US]/[US]
Inventors
  • ELIASEN, Anders
Agents
  • HODGES, Robert A.
  • PABST, Patrea L.
  • SHYNTUM, Yvonne Y.
  • MONHEIT, Rivka D.
  • SARGSYAN, S. Anna
  • RAYMOND, Adam S.
  • YONGYE, Austin B.
  • CALDERON MOLINA, Angie D.
  • ZUNIGA, Carlos A.
  • XU, Xiaojin
Priority Data
62/755,40302.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PEPTIDE LIBRARIES WITH NON-CANONICAL AMINO ACIDS
(FR) BANQUES DE PEPTIDES AVEC DES ACIDES AMINÉS NON CANONIQUES
Abstract
(EN)
Disclosed are peptides having non-canonical amino acids. These peptides are useful, for example, as protein binding agents. Libraries of such peptides can be used, for example to screen and select protein binding agents. The broader chemical space of the disclosed peptides can provide peptide with different, improved, more specific, and/or pharmaceutically compatible peptides and protein binding agents. In some forms, the peptides can have structure (I): (I) including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1 Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed.
(FR)
L'invention concerne des peptides ayant des acides aminés non canoniques. Lesdits peptides sont utiles, par exemple, en tant qu'agents de liaison à des protéines. Des banques de ces peptides peuvent être utilisées par exemple pour cribler et sélectionner des agents de liaison à des protéines. L'espace chimique plus large des peptides décrits peut fournir un peptide avec des peptides différents, améliorés, plus spécifiques et/ou pharmaceutiquement compatibles et des agents de liaison à des protéines. Dans certains modes de réalisation, les peptides peuvent avoir une structure (I) : (I) comprenant des stéréoisomères, des sels pharmaceutiquement acceptables et des promédicaments de ceux-ci. Dans ladite formule, R, R1, L1, L2, G, M, Y1, Y2 et SEQ sont tels que définis dans la description. La présente invention concerne en outre des méthodes associées à la préparation et à l’utilisation de ces peptides, ainsi que des compositions pharmaceutiques comprenant lesdits peptides.
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