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1. WO2020093047 - METHODS AND COMPOSITIONS FOR TREATMENT OF TYPE 1 DIABETES USING FIBROBLASTS AS FACILITATORS OF ISLET ENGRAFTMENT

Publication Number WO/2020/093047
Publication Date 07.05.2020
International Application No. PCT/US2019/059666
International Filing Date 04.11.2019
IPC
A61K 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
A61K 35/12 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61K 45/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61P 1/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • FIGENE, LLC [US]/[US]
Inventors
  • O'HEERON, Pete
  • ICHIM, Thomas
Agents
  • MELISSA SISTRUNK
Priority Data
62/755,52304.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR TREATMENT OF TYPE 1 DIABETES USING FIBROBLASTS AS FACILITATORS OF ISLET ENGRAFTMENT
(FR) MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DU DIABÈTE DE TYPE 1 UTILISANT DES FIBROBLASTES EN TANT QUE FACILITEURS DE LA PRISE DE GREFFE D'ÎLOTS
Abstract
(EN)
Embodiments of the disclosure pertain to the treatment of diabetes through replacement of insulin producing cells. In specific embodiments, the disclosure encompasses the use of cellular adjuvants to enhance survival, engraftment and tolerogenesis of insulin-producing cells. In certain cases the disclosure concerns the manipulation of a hepatic microenvironment to promote immunological tolerance at an enhanced level to allow for integration of allogeneic insulin-producing cells. Particular embodiments utilize fibroblasts to enhance immunological tolerance for insulin-producing cells upon engraftment.
(FR)
Dans des modes de réalisation, l'invention concerne le traitement du diabète par le remplacement de cellules productrices d'insuline. Dans des modes de réalisation spécifiques, l'invention porte sur l'utilisation d'adjuvants cellulaires pour améliorer la survie, la prise de greffe et la tolérogenèse de cellules productrices d'insuline. Dans certains cas, l'invention concerne la manipulation d'un microenvironnement hépatique pour favoriser une tolérance immunologique à un niveau amélioré afin de permettre l'intégration de cellules allogéniques productrices d'insuline. Des modes de réalisation particuliers utilisent des fibroblastes pour améliorer la tolérance immunologique vis-à-vis des cellules productrices d'insuline lors de la prise de greffe.
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