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1. WO2020093008 - PHOSPHATE COMPOUNDS FOR DETECTING NEUROLOGICAL DISORDERS

Publication Number WO/2020/093008
Publication Date 07.05.2020
International Application No. PCT/US2019/059538
International Filing Date 01.11.2019
IPC
A61K 31/437 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/4375 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4375the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 31/4725 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
4725containing further heterocyclic rings
Applicants
  • SARRAF, Stella [US]/[US]
  • RANDOLPH, Lyndsay M. [US]/[US]
  • RASOOL, Suhail [US]/[US]
Inventors
  • SARRAF, Stella
  • RANDOLPH, Lyndsay M.
  • RASOOL, Suhail
Agents
  • TANNER, Lorna L.
  • HIRAYAMA, Lacie C.
  • NEMIROW, Joy L.
  • NIE, Alex Y.
  • SAHASRABUDHE, Kiran
  • TURNER, Dylan
Priority Data
62/755,33102.11.2018US
62/855,44231.05.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHOSPHATE COMPOUNDS FOR DETECTING NEUROLOGICAL DISORDERS
(FR) COMPOSÉS DE PHOSPHATE POUR DÉTECTER DES TROUBLES NEUROLOGIQUES
Abstract
(EN)
Provided herein are compounds, methods and compositions for determining whether a patient has a neurological disease or disorder is provided, comprising detecting the presence of a detectable target protein, or an accumulated mass thereof, for example, amyloid beta protein or phosphorylated tau protein, or an accumulated mass thereof, in a tissue or a sample of the patient. The detecting may comprise contacting the target protein with a compound described herein.
(FR)
L'invention concerne des composés, des procédés et des compositions pour déterminer si un patient a une maladie ou un trouble neurologique, comprenant la détection de la présence d'une protéine cible détectable, ou d'une masse accumulée de celle-ci, par exemple, la protéine bêta-amyloïde ou la protéine tau phosphorylée, ou une masse accumulée de celle-ci, dans un tissu ou un échantillon du patient. La détection peut comprendre la mise en contact de la protéine cible avec un composé décrit ici.
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