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1. WO2020092910 - TARGETING REDOX-ACTIVE PYRIDINIUM CATIONS TO MITOCHONDRIA TO INHIBIT PROLIFERATION OF DRUG-RESISTANT CANCER CELLS

Publication Number WO/2020/092910
Publication Date 07.05.2020
International Application No. PCT/US2019/059404
International Filing Date 01.11.2019
IPC
C07D 213/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D 213/20 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
16containing only one pyridine ring
20Quaternary compounds thereof
Applicants
  • THE MEDICAL COLLEGE OF WISCONSIN, INC. [US]/[US]
  • LODZ UNIVERSITY OF TECHNOLOGY [US]/[US]
Inventors
  • ZIELONKA, Jacek, Michal
  • SIKORA, Adam, Bartlomiej
  • KALYANARAMAN, Balaraman
Agents
  • BABEL, Angeline, R.
Priority Data
62/754,48801.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TARGETING REDOX-ACTIVE PYRIDINIUM CATIONS TO MITOCHONDRIA TO INHIBIT PROLIFERATION OF DRUG-RESISTANT CANCER CELLS
(FR) CIBLAGE DE CATIONS DE PYRIDINIUM À ACTIVITÉ REDOX SUR LES MITOCHONDRIES POUR INHIBER LA PROLIFÉRATION DE CELLULES CANCÉREUSES RÉSISTANTES AUX MÉDICAMENTS
Abstract
(EN)
The present invention provides novel mito-pyridinium compounds, prodrugs and the uses thereof for the treatment of cancer, particularly drug resistant cancer.
(FR)
La présente invention concerne de nouveaux composés de mito-pyridinium, des promédicaments et des utilisations associées pour le traitement du cancer, en particulier du cancer résistant aux médicaments.
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