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1. WO2020092815 - IMPROVED INTRA-ARTERIAL TUMOR TARGETING FOR DIAGNOSIS AND/OR TREATMENT

Publication Number WO/2020/092815
Publication Date 07.05.2020
International Application No. PCT/US2019/059226
International Filing Date 31.10.2019
IPC
A61K 9/107 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 47/44 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42107; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • MEMORIAL SLOAN KETTERING CANCER CENTER [US]/[US]
Inventors
  • BOAS, Franz Edward
  • ERINJERI, Joseph
Agents
  • MCPARLAND, James P.
  • EWING, James F.
Priority Data
62/754,13901.11.2018US
62/817,11612.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED INTRA-ARTERIAL TUMOR TARGETING FOR DIAGNOSIS AND/OR TREATMENT
(FR) CIBLAGE DE TUMEUR INTRA-ARTÉRIEL AMÉLIORÉ POUR UN DIAGNOSTIC ET/OU UN TRAITEMENT
Abstract
(EN)
The present disclosure relates provides methods for diagnosing and/or treating a tumor in a subject. The methods of the present technology relate to localized intra-arterial delivery to a tumor using a carrier including an omniphobic fluid to improve tumor uptake, specificity, and retention. The carrier may also include a low viscosity oil to enhance extravasation through tumor vasculature. The methods of the present technology also relate to localized intra- arterial delivery of a vaccine adjuvant into a tumor, using a carrier to improve tumor uptake, specificity, and retention. The carrier may include, for example, lipiodol, an omniphobic oil, and/or particles, and may also include a low viscosity oil to enhance extravasation through tumor vasculature.
(FR)
La présente invention concerne des méthodes pour diagnostiquer et/ou traiter une tumeur chez un sujet. Les méthodes de la présente invention concernent l'administration intra-artérielle localisée à une tumeur à l'aide d'un support comprenant un liquide omniphobe pour améliorer l'absorption, la spécificité et la rétention de tumeur. Le support peut également comprendre une huile à faible viscosité pour améliorer l'extravasation à travers le système vasculaire tumoral. Les méthodes de la présente invention concernent également l'administration intra-artérielle localisée d'un adjuvant de vaccin dans une tumeur, à l'aide d'un support pour améliorer l'absorption, la spécificité et la rétention de tumeur. Le support peut comprendre, par exemple, du lipiodol, une huile omniphobe et/ou des particules, et peut également comprendre une huile à faible viscosité pour améliorer l'extravasation à travers le système vasculaire tumoral.
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