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1. WO2020092763 - METHODS FOR COMPARING EFFICACY OF DONOR MOLECULES

Publication Number WO/2020/092763
Publication Date 07.05.2020
International Application No. PCT/US2019/059154
International Filing Date 31.10.2019
IPC
G16B 20/00 2019.01
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
CPC
C12N 15/1082
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
1034Isolating an individual clone by screening libraries
1082Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
C12N 15/907
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
90Stable introduction of foreign DNA into chromosome
902using homologous recombination
907in mammalian cells
C12Q 1/6869
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6869Methods for sequencing
G16B 20/00
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
20ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
Applicants
  • BLUEALLELE, LLC [US]/[US]
Inventors
  • BALTES, Nicholas
Agents
  • SWEENEY, Patricia, A.
  • MCKEE, Bruce, W.
  • SEASE, Edmund, J.
  • HANSING, Mark, D.
  • HARTUNG, Kirk, M.
  • NEBEL, Heidi, S.
  • EDGAR, Cassandra, Joan
  • LINK, Jill, N.
  • JOHNSON, R., Scott
  • GILCHRIST, Michael, C.
  • MOHRHAUSER, Luke, T.
  • KENNEDY, Jonathan, L.
  • GUNNERSON, Gregory, Lars
  • DICKHUT, Sarah, M.
  • KEPPLER, Brian, D.
  • SOWATZKE, Tina, Yin
Priority Data
62/755,46303.11.2018US
62/828,52003.04.2019US
62/873,26412.07.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR COMPARING EFFICACY OF DONOR MOLECULES
(FR) MÉTHODES DE COMPARAISON D'EFFICACITÉ DE MOLÉCULES DONNEUSES
Abstract
(EN)
Methods for gene targeting or targeted insertion in cells. The methods and compositions described herein can be used to identify the relative frequency of donor molecule integration.
(FR)
L'invention concerne des méthodes de ciblage génique ou d'insertion ciblée dans des cellules. Les méthodes et les compositions selon l'invention peuvent servir à identifier la fréquence relative d'intégration de molécules donneuses.
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