Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020092705 - SELF-ASSEMBLING PEPTIDES AND HYDROGELS

Publication Number WO/2020/092705
Publication Date 07.05.2020
International Application No. PCT/US2019/059052
International Filing Date 31.10.2019
IPC
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
C07K 7/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
C07K 5/11 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
10Tetrapeptides
11the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
C40B 40/10 2006.01
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40Libraries per se, e.g. arrays, mixtures
04Libraries containing only organic compounds
10Libraries containing peptides or polypeptides, or derivatives thereof
C40B 20/08 2006.01
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
20Methods specially adapted for identifying library members
08Direct analysis of the library members per se by physical methods, e.g. spectroscopy
C40B 30/10 2006.01
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30Methods of screening libraries
10by measuring physical properties, e.g. mass
Applicants
  • UNIVERSITY OF VIRGINIA PATENT FOUNDATION [US]/[US]
Inventors
  • LAMPE, Kyle Jay
  • TANG, James D.
Agents
  • SCHABOWSKY, Richard Henry
  • MCNEELY, Richard J.
  • GOULD, Weston R.
  • LUNN, Jennifer H.
  • NEAL, Cynthia A.
  • WILLIAMS, JR., Larry D.
  • O'SHAUGHNESSY, Brian P.
Priority Data
62/753,43631.10.2018US
62/813,89305.03.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SELF-ASSEMBLING PEPTIDES AND HYDROGELS
(FR) PEPTIDES ET HYDROGELS À AUTO-ASSEMBLAGE
Abstract
(EN)
Novel self-assembling pentapeptides and peptides containing such self-assembling pentapeptides, self-assembled hydrogels, and methods of making and using the same are described. These pentapeptides, and peptides containing such pentapeptides, self-assemble under physiological conditions (e.g., in a physiological buffer under biologically acceptable conditions (e.g., pH ≈ 6-11)) into long fibrils with sequence-dependent fibrillary morphologies. The hydrogels comprise one or more these pentapeptides which make up the 3-dimensional nanofibrous network of the hydrogel structure. The hydrogels are shear-thinning hydrogels that have high storage moduli and high rates of recovery after destruction. These hydrogels are useful in various applications, including but not limited to, scaffolds for tissue engineering, 2-dimensional (2-D) and 3-dimensional (3-D) cell cultures, drug delivery and encapsulation of therapeutic agents (cells, molecules, drugs, compounds), injectables (including those that gel in situ, such as hemostatic compositions), hemostatic agents, wound dressings, pharmaceutical carriers or vehicles, cell transplantation, cell storage, virus culture, and virus storage.
(FR)
L'invention concerne de nouveaux pentapeptides à auto-assemblage et des peptides contenant de tels pentapeptides à auto-assemblage, des hydrogels à auto-assemblage, et des procédés de fabrication et d'utilisation de ceux-ci. Les pentapeptides, et les peptides contenant de tels pentapeptides, s'auto-assemblent dans des conditions physiologiques (par exemple, dans un tampon physiologique dans des conditions biologiquement acceptables (par exemple, pH ≈ 6-11)) en fibrilles longues ayant des morphologies fibrillaires dépendantes de la séquence. Les hydrogels comprennent un ou plusieurs de ces pentapeptides qui constituent une structure nanofibreuse tridimensionnelle de la structure d'hydrogel. Les hydrogels sont des hydrogels à rhéofluidification qui présentent des modules de stockage élevés et des taux élevés de récupération après destruction. Ces hydrogels sont utiles dans diverses applications, comprenant, mais sans y être limitées, des échafaudages pour l'ingénierie tissulaire, des cultures cellulaires bidimensionnelles (2-D) et tridimensionnelles (3-D), dans l'administration de médicament et l'encapsulation d'agents thérapeutiques (cellules, molécules, médicaments, composés), dans des produits injectables (y compris ceux qui se gélifient in situ, tels que des compositions hémostatiques), des agents hémostatiques, des pansements, des supports ou des véhicules pharmaceutiques, la transplantation cellulaire, le stockage cellulaire, la culture de virus et le stockage de virus.
Latest bibliographic data on file with the International Bureau