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1. WO2020092693 - METHOD FOR SYNTHESIZING D3 DOPAMINE RECEPTOR AGONISTS

Publication Number WO/2020/092693
Publication Date 07.05.2020
International Application No. PCT/US2019/059036
International Filing Date 31.10.2019
IPC
A61K 31/135 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
C07C 211/26 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
211Compounds containing amino groups bound to a carbon skeleton
01having amino groups bound to acyclic carbon atoms
26of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
Applicants
  • POLYCORE THERAPEUTICS LLC [US]/[US]
Inventors
  • SIELECKI-DZURDZ, Thais Motria
  • MI, Baoyu
  • ZHAO, Huiping
  • KORTAGERE, Sandhya
Agents
  • ZELLEY, Geoffrey A.
Priority Data
62/753,27531.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR SYNTHESIZING D3 DOPAMINE RECEPTOR AGONISTS
(FR) PROCÉDÉ DE SYNTHÈSE D'AGONISTES DU RÉCEPTEUR D3 DE LA DOPAMINE
Abstract
(EN)
An improved method for synthesizing a compound according to formula (I) by reaction of a compound of formula (II) with a sulfinamide according to formula (III). The resultant compound is then reduced and hydrolyzed, and optionally alkylated or arylated to arrive at the compound according to formula (I).
(FR)
L'invention concerne un procédé amélioré de synthèse d'un composé selon la formule (I) par réaction d'un composé de formule (II) avec un sulfinamide selon la formule (III). Le composé obtenu est ensuite réduit et hydrolysé, et éventuellement alkylé ou arylé pour parvenir au composé selon la formule (I).
Latest bibliographic data on file with the International Bureau