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1. WO2020092682 - METHODS AND COMPOSITIONS FOR TREATING HEPATOCELLULAR CARCINOMA USING ANTISENSE

Publication Number WO/2020/092682
Publication Date 07.05.2020
International Application No. PCT/US2019/059017
International Filing Date 31.10.2019
IPC
A61K 35/13 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
13Tumour cells, irrespective of tissue of origin
A61K 35/12 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61K 35/28 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
Applicants
  • THOMAS JEFFERSON UNIVERSITY [US]/[US]
Inventors
  • HOOPER, Douglas, Craig
  • ANDREWS, David
  • BONGIOMO, Emily
Agents
  • HAAS, Dennis, L.
  • ALLEN, Justin
  • ALLEN, Scott, E.
  • CHEN, Xu Ming, Ming
  • ARTIS, Ryan
Priority Data
62/755,06402.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR TREATING HEPATOCELLULAR CARCINOMA USING ANTISENSE
(FR) MÉTHODES ET COMPOSITIONS POUR TRAITER UN CARCINOME HÉPATOCELLULAIRE EN FAISANT APPEL À DES ACIDES NUCLÉIQUES ANTISENS
Abstract
(EN)
The present disclosure relates to compositions and methods for treating liver cancers, especially hepatocellular carcinoma, using antisense (AS) nucleic acids directed against Insulin- like Growth Factor 1 Receptor (1GF-1R). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of liver cancer.
(FR)
La présente invention concerne des compositions et des méthodes pour traiter des cancers hépatiques, en particulier un carcinome hépatocellulaire, en faisant appel à des acides nucléiques antisens (AS) dirigés contre le récepteur du facteur de croissance 1 de type insuline (IGF-1R). Les AS peuvent être administrés aux patients de manière systémique, ou peuvent être utilisés pour produire un vaccin à cellules cancéreuses autologues. Dans certains modes de réalisation, les AS sont placés dans une chambre de biodiffusion implantable exposée à un rayonnement comprenant des cellules tumorales et une quantité efficace des AS. Les chambres sont exposées à un rayonnement et implantées dans l'abdomen de sujets et stimulent une réponse immunitaire qui attaque les tumeurs à distance. Les compositions et les méthodes décrites dans la description peuvent être utilisées pour traiter de nombreux types de cancers hépatiques différents.
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