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1. WO2020092621 - SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS

Publication Number WO/2020/092621
Publication Date 07.05.2020
International Application No. PCT/US2019/058932
International Filing Date 30.10.2019
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A61K 31/437 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applicants
  • GILEAD SCIENCES, INC. [US]/[US]
Inventors
  • BALAN, Gayatri
  • BARTLETT, Mark J.
  • CHANDRASEKHAR, Jayaraman
  • CODELLI, Julian A.
  • CONWAY, John H.
  • COSMAN, Jennifer L.
  • KALLA, Rao V.
  • KASUN, Zachary A.
  • KIM, Musong
  • LEE, Seung H.
  • LO, Jennifer R.
  • LOYER-DREW, Jennifer A.
  • MITCHELL, Scott A.
  • PERRY, Thao D.
  • PHILLIPS, Gary B.
  • SALVO, Patrick J.
  • SWAMINATHAN, Sundaramoorthi
  • VAN VELDHUIZEN, Joshua J.
  • YEUNG, Suet C.
  • ZABLOCKI, Jeff
Agents
  • BAJPAI, Reena
  • AMIRGHOLIZADEH, Tashica T.
  • BARRON, Briana R.
  • BOSS, Brandon
  • BRINKER, Achim
  • CHOI, Lydia B.
  • DAMMANN, Yu-Ming
  • EDWARDS, Mary J.
  • GHOSH, Samantak
  • GINAH, Francis O.
  • GRESSLER, Donna
  • HARTRUM, J. Elin
  • HUTCHISON, Andrea
  • LAI, Shelley
  • MARQUART, Timothy A.
  • POLSTER, Philip B.
  • RICE, Katharine R.
  • SILVER, Joel
  • SIMPSON, Alexis N.
  • STUART, Tara C.
  • WAHLSTEN, Jennifer L.
  • YANG, Liuchun
Priority Data
62/753,33931.10.2018US
62/868,55028.06.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS
(FR) COMPOSÉS DE 6-AZABENZIMIDAZOLE SUBSTITUÉS EN TANT QU'INHIBITEURS DE HPK1
Abstract
(EN)
The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
(FR)
La présente invention concerne de manière générale certains composés de 6-azabenzimidazole, des compositions pharmaceutiques comprenant lesdits composés, et des procédés de fabrication et d'utilisation desdits composés et compositions pharmaceutiques. Les composés et les compositions de l'invention peuvent être utilisés pour le traitement ou la prévention de maladies, de troubles ou d'infections modifiables par des inhibiteurs de kinases progénitrices hématopoïétiques (HPK1), tels que le VHB, le VIH, le cancer et/ou une maladie hyper-proliférative.
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