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1. WO2020092615 - TREATMENTS FOR VENETOCLAX-RESISTANT AND VENETOCLAX-SENSITIVE ACUTE MYELOID LEUKEMIA

Publication Number WO/2020/092615
Publication Date 07.05.2020
International Application No. PCT/US2019/058923
International Filing Date 30.10.2019
IPC
A61K 31/519 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Applicants
  • OREGON HEALTH & SCIENCE UNIVERSITY [US]/[US]
Inventors
  • TYNER, Jeffrey W.
  • ZHANG, Haijiao
Agents
  • ECK, Steven R.
Priority Data
62/754,38601.11.2018US
62/774,08730.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TREATMENTS FOR VENETOCLAX-RESISTANT AND VENETOCLAX-SENSITIVE ACUTE MYELOID LEUKEMIA
(FR) TRAITEMENTS DE LA LEUCÉMIE MYÉLOÏDE AIGUË RÉSISTANTE AU VÉNÉTOCLAX ET SENSIBLE AU VÉNÉTOCLAX
Abstract
(EN)
Provided herein are methods and therapeutic combinations useful in the treatment of venetoclax-resistant Acute Myeloid Leukemia and of venetoclax-sensitive Acute Myeloid Leukemia.
(FR)
L'invention concerne des méthodes et des combinaisons thérapeutiques utiles dans le traitement de la leucémie myéloïde aiguë résistante au vénétoclax et de la leucémie myéloïde aiguë sensible au vénétoclax.
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