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1. WO2020092605 - COMPOSITIONS AND METHODS FOR MODULATING EGG DEVELOPMENT IN MOSQUITOES

Publication Number WO/2020/092605
Publication Date 07.05.2020
International Application No. PCT/US2019/058910
International Filing Date 30.10.2019
IPC
A01P 7/04 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
PBIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
7Arthropodicides
04Insecticides
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
A01N 25/26 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
26in coated particulate form
Applicants
  • ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US]/[US]
Inventors
  • ISOE, Jun
  • MIESFELD, Roger
Agents
  • RAYMOND, Adam S.
  • PABST, Patrea L.
  • HODGES, Robert A.
  • SHYNTUM, Yvonne Y.
  • MONHEIT, Rivka D.
  • SARGSYAN, S. Anna
  • YONGYE, Austin B.
  • CALDERON MOLINA, Angie D.
  • ZUNIGA, Carlos A.
  • XU, Xiaojin
Priority Data
62/752,88030.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR MODULATING EGG DEVELOPMENT IN MOSQUITOES
(FR) COMPOSITIONS ET PROCÉDÉS POUR MODULER LE DÉVELOPPEMENT DES ŒUFS CHEZ LES MOUSTIQUES
Abstract
(EN)
Compositions and methods for reducing or preventing mosquito egg development are provided. Typically, the compositions include an effective amount of a compound that reduces, inhibits, or prevents, expression of a mosquito EOF1, Nasrat, Closca, Polehole Nudel, CATL3, DCE2, DCE4, or DCE5 gene, or a gene product thereof, for example EOF1 or Nudel mRNA or protein. The compound can be a functional nucleic acid such as antisense molecule, siRNA, miRNA, ribozymes, RNAi, or external guide sequences, a gene editing composition, or a protease inhibitor. The disclosed methods typically include contacting mosquito cells with an effective amount of one or more of the disclosed compositions, and can be used to reduce, inhibit, or prevent egg development in an effective number of mosquitoes to reduce transmission of one or more infections or diseases.
(FR)
La présente invention concerne des compositions et des procédés destinés à limiter ou prévenir le développement des œufs de moustique. Typiquement, les compositions comprennent une quantité efficace d'un composé qui réduit, inhibe ou prévient l'expression d'un gène EOF1, Nasrat, Closca, Polehole Nudel, CATL3, DCE2, DCE4 ou DCE5 de moustique, ou d'un produit génique de celui-ci, par exemple EOF1 ou l'ARNm ou la protéine Nudel. Le composé peut être un acide nucléique fonctionnel tel qu'une molécule antisens, un ARNsi, un miARN, des ribozymes, un ARNi ou des séquences guides externes, une composition d'édition de gène ou un inhibiteur de protéase. Les procédés décrits comprennent typiquement la mise en contact de cellules de moustique avec une quantité efficace d'une ou plusieurs des compositions décrites, et ils peuvent être utilisés pour limiter, inhiber ou prévenir le développement des œufs chez un nombre suffisant de moustiques pour réduire la transmission d'une ou plusieurs infections ou maladies.
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