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1. WO2020092604 - DEUTERATED PITOLISANT

Publication Number WO/2020/092604
Publication Date 07.05.2020
International Application No. PCT/US2019/058909
International Filing Date 30.10.2019
IPC
A61K 31/137 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
135having aromatic rings, e.g. methadone
137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/4402 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4402only substituted in position 2, e.g. pheniramine, bisacodyl
Applicants
  • CONCERT PHARMACEUTICALS, INC. [US]/[US]
  • TUNG, Roger D. [US]/[US]
  • LIU, Julie F. [US]/[US]
  • HURST, Raymond S. [US]/[US]
Inventors
  • TUNG, Roger D.
  • LIU, Julie F.
  • HURST, Raymond S.
Agents
  • IGNATENKO, Vasily A.
  • LAVOIE, Teresa A.
Priority Data
62/752,60030.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DEUTERATED PITOLISANT
(FR) PITOLISANT DEUTÉRÉ
Abstract
(EN)
This invention also provides compound of Formula (I) including pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable carrier. This invention also provides the use of such compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering pitolisant. Some exemplary embodiments include a method of treating a disease or condition selected from narcolepsy, daytime sleepiness (particularly in subjects suffering from Parkinson's disease or obstructive sleep apnea syndrome), and cognitive defects in psychiatric conditions, the method comprising the step of administering to a subject in need thereof a pharmaceutically acceptable composition of the present invention.
(FR)
Cette invention concerne un composé de formule (I) notamment des compositions pharmaceutiques comprenant un composé de formule (I) et un excipient pharmaceutiquement acceptable. L'invention concerne également l'utilisation de tels composés et de telles compositions dans des méthodes de traitement de maladies et d'affections qui sont traitées avantageusement par l'administration de pitolisant. Certains modes de réalisation donnés à titre d'exemple comprennent une méthode de traitement d'une maladie ou d'une affection choisie parmi la narcolepsie, la somnolence diurne (en particulier chez des sujets souffrant de la maladie de Parkinson ou du syndrome d'apnées obstructives du sommeil) et des déficiences cognitives dans des affections psychiatriques, la méthode comprenant l'étape consistant à administrer à un sujet qui en a besoin une composition pharmaceutiquement acceptable selon la présente invention.
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