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1. WO2020092401 - COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN

Publication Number WO/2020/092401
Publication Date 07.05.2020
International Application No. PCT/US2019/058610
International Filing Date 29.10.2019
IPC
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07C 233/73 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
67having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
68with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
73of a carbon skeleton containing six-membered aromatic rings
C07D 213/61 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
61Halogen atoms or nitro radicals
C07D 215/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
12with substituted hydrocarbon radicals attached to ring carbon atoms
14Radicals substituted by oxygen atoms
C07D 239/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
C07D 249/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
06with aryl radicals directly attached to ring atoms
CPC
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
C07C 233/73
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
67having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
68with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
73of a carbon skeleton containing six-membered aromatic rings
C07D 213/61
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
61Halogen atoms or nitro radicals
C07D 215/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
12with substituted hydrocarbon radicals attached to ring carbon atoms
14Radicals substituted by oxygen atoms
C07D 239/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
C07D 249/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
06with aryl radicals directly attached to ring atoms
Applicants
  • GILEAD SCIENCES, INC. [US]/[US]
Inventors
  • BLOMGREN, Peter A.
  • CAMPBELL, Taryn
  • CHANDRASEKHAR, Jayaraman
  • CLARK, Christopher T.
  • CODELLI, Julian A.
  • CURRIE, Kevin S.
  • KROPF, Jeffrey E.
  • MOAZAMI, Yasamin
  • NAVA, Nicole
  • PATEL, Leena
  • PERREAULT, Stephane
  • PERRY, Jason K.
  • SEDILLO, Kassandra F.
  • SEEGER, Natalie
  • STEVENS, Kirk L.
  • TREIBERG, Jennifer Anne
  • YEUNG, Suet C.
  • ZHAO, Zhongdong
Agents
  • YANG, Liuchun
  • AMIRGHOLIZADEH, Tashica T.
  • BAJPAI, Reena
  • BARRON, Briana R.
  • BOSS, Brandon
  • BRINKER, Achim
  • CHOI, Lydia B.
  • DAMMANN, Yu-Ming
  • EDWARDS, Mary J.
  • GINAH, Francis O.
  • GRESSLER, Donna
  • HARTRUM, J. Elin
  • HUTCHISON, Andrea
  • LAI, Shelley
  • MARQUART, Timothy A.
  • POLSTER, Philip B.
  • RICE, Katharine R.
  • SILVER, Joel
  • SIMPSON, Alexis N.
  • STUART, Tara C.
  • WAHLSTEN, Jennifer L.
Priority Data
62/752,85430.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS FOR INHIBITION OF ALPHA 4β7 INTEGRIN
(FR) COMPOSÉS POUR INHIBITION DE L'INTÉGRINE ALPHA 4β7
Abstract
(EN)
The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
(FR)
La présente invention concerne un composé de formule (I) : ou un sel pharmaceutiquement acceptable de celui-ci tel que décrit ici. La présente invention concerne également des compositions pharmaceutiques comprenant un composé de formule (I), des procédés de préparation de composés de formule (I), et des procédés thérapeutiques pour traiter une maladie inflammatoire.
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