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1. WO2020092376 - TREATING NON-ALCOHOLIC STEATOHEPATITIS (NASH)

Publication Number WO/2020/092376
Publication Date 07.05.2020
International Application No. PCT/US2019/058575
International Filing Date 29.10.2019
IPC
A01N 57/00 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
57Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
A61K 31/665 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
66Phosphorus compounds
665having oxygen as a ring hetero atom, e.g. fosfomycin
Applicants
  • FORMA THERAPEUTICS, INC. [US]/[US]
Inventors
  • LUKE, George
  • WALKER, Duncan
  • KELLY, Patrick, J.
Agents
  • MARSHALL, Ryan, L.
  • NEY, Joshua
Priority Data
62/752,23129.10.2018US
62/844,96308.05.2019US
62/844,97108.05.2019US
62/856,38303.06.2019US
62/856,39103.06.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TREATING NON-ALCOHOLIC STEATOHEPATITIS (NASH)
(FR) TRAITEMENT DE LA STÉATOHÉPATITE NON ALCOOLIQUE (SHNA)
Abstract
(EN)
The present disclosure describes the therapeutic administration of a fatty acid synthase (FASN) inhibitor (Compound 1), including via intermittent dosing regimens, to patients diagnosed with non-alcoholic steatohepatitis (NASH) characterized by hepatic steatosis, inflammation, and fibrosis.
(FR)
La présente invention concerne l'administration thérapeutique d'un inhibiteur d'acide gras synthase (FASN) (composé 1), y compris via des schémas posologiques intermittents, à des patients diagnostiqués avec une stéatohépatite non alcoolique (SHNA) caractérisée par une stéatose hépatique, une inflammation et une fibrose.
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