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1. WO2020092355 - NANOBODY-GLYCAN MODIFYING ENZYME FUSION PROTEINS AND USES THEREOF

Publication Number WO/2020/092355
Publication Date 07.05.2020
International Application No. PCT/US2019/058546
International Filing Date 29.10.2019
IPC
A61K 47/68 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
Applicants
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]/[US]
Inventors
  • WOO, Christina, M.
  • RAMIREZ, Daniel, Hector
  • AONBANGKHEN, Chanat
Agents
  • WILLIAMS, Andrew, W.
  • BAKER, C., Hunter
  • ALAM, Saad
  • AMUNDSEN, Eric, L.
  • ATTISHA, Michael, J.
Priority Data
62/752,18629.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NANOBODY-GLYCAN MODIFYING ENZYME FUSION PROTEINS AND USES THEREOF
(FR) PROTÉINES DE FUSION D'ENZYME DE MODIFICATION DE NANOCORPS-GLYCANE ET LEURS UTILISATIONS
Abstract
(EN)
The present disclosure provides fusion proteins comprising a nanobody and a glycan modifying enzyme. Also provided herein are methods of glycosylating a protein and methods of removing a sugar from a protein. Further provided in the present disclosure are methods of treating and/or diagnosing diseases. Also provided herein are kits, polynucleotides, vectors, and cells.
(FR)
La présente invention concerne des protéines de fusion comprenant une enzyme de modification de nanocorps et de glycane. L'invention concerne également des procédés de glycosylation d'une protéine et des procédés d'élimination d'un sucre d'une protéine. La présente invention concerne en outre des méthodes de traitement et/ou de diagnostic de maladies. L'invention concerne également des kits, des polynucléotides, des vecteurs et des cellules.
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