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1. WO2020092352 - TABLETS, FORMULATIONS AND METHODS FOR LOW MELTING POINT ACTIVE INGREDIENTS

Publication Number WO/2020/092352
Publication Date 07.05.2020
International Application No. PCT/US2019/058537
International Filing Date 29.10.2019
IPC
A61K 9/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 31/352 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
CPC
A61K 31/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 9/2004
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
A61K 9/2013
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
A61K 9/2018
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
A61K 9/2054
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
205Polysaccharides, e.g. alginate, gums; Cyclodextrin
2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Applicants
  • KELSIE BIOTECH, LLC [US]/[US]
Inventors
  • REBITS, Lia
  • GILDELAMADRID, Xuno
Agents
  • KOZLOWSKI, Holly
Priority Data
62/752,71930.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TABLETS, FORMULATIONS AND METHODS FOR LOW MELTING POINT ACTIVE INGREDIENTS
(FR) COMPRIMÉS, FORMULATIONS ET PROCÉDÉS POUR INGRÉDIENTS ACTIFS À BAS POINT DE FUSION
Abstract
(EN)
A tablet comprises a granulate of an active pharmaceutical ingredient comprising at least one cannabinoid having a melting point less than about 80 °C; sugar, sugar alcohol, or a combination thereof; microcrystalline cellulose having an average particle size less than about 25 µm; silica, silicified microcrystalline cellulose, or a combination thereof; and lubricant comprising sodium stearyl fumarate and lecithin. Methods of forming such a tablet using direct compression of a tablet formulation can be conducted on a large manufacturing scale.
(FR)
L'invention concerne un comprimé qui comprend un granulé d'un ingrédient pharmaceutique actif comprenant au moins un cannabinoïde ayant un point de fusion inférieur à environ 80 °C ; du sucre, de l'alcool de sucre ou une combinaison de ceux-ci ; de la cellulose microcristalline ayant une taille moyenne de particule inférieure à environ 25 µm ; de la silice, de la cellulose microcristalline silicifiée ou une combinaison de celles-ci ; et un lubrifiant comprenant du stéarylfumarate de sodium et de la lécithine. Des procédés de formation d'un tel comprimé par compression directe d'une formulation de comprimé peuvent être mis en oeuvre pour la fabrication à grande échelle.
Latest bibliographic data on file with the International Bureau