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1. WO2020092342 - SILICA-BASED DRUG NANOCAPSULES

Publication Number WO/2020/092342
Publication Date 07.05.2020
International Application No. PCT/US2019/058525
International Filing Date 29.10.2019
IPC
A23L 27/00 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
27Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
A61K 8/11 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
11Encapsulated compositions
A61K 9/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
Applicants
  • UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. [US]/[US]
Inventors
  • XIE, Jin
  • ZHANG, Weizhong
Agents
  • CLEVELAND, Janell T.
  • CURFMAN, Christopher L.
  • HALL, Miles E.
Priority Data
62/751,83329.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SILICA-BASED DRUG NANOCAPSULES
(FR) NANOCAPSULES DE MÉDICAMENT À BASE DE SILICE
Abstract
(EN)
Disclosed herein are nanoparticles comprising a therapeutic or diagnostic agent positioned within an orthosilicate inner matrix, and a silica outer shell encapsulating the orthosilicate inner matrix. Also disclosed are methods of treating a disease in a subject comprising administering to the subject a biological carrier cell comprising the nanoparticle. Also disclosed are methods of preparing nanoparticles, methods of delivering nanoparticles comprising a therapeutic or diagnostic agent to a target cell, and methods of loading a therapeutic or diagnostic agent into a biological carrier cell.
(FR)
L'invention concerne des nanoparticules comprenant un agent thérapeutique ou de diagnostic positionné à l'intérieur d'une matrice interne d'orthosilicate, et une enveloppe externe en silice encapsulant la matrice interne d'orthosilicate. L'invention concerne également des procédés de traitement d'une maladie chez un sujet, comprenant l'administration au sujet d'une cellule de support biologique comprenant la nanoparticule. L'invention concerne également des procédés de préparation de nanoparticules, des procédés d'administration de nanoparticules comprenant un agent thérapeutique ou de diagnostic à une cellule cible, et des procédés de chargement d'un agent thérapeutique ou de diagnostic dans une cellule de support biologique.
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